Targeting agents,active

Inhibition of IGF-IR autophosphorylation by NVP-ADW742 results in a plethora of pro-apoptotic molecular events that may account for its effectiveness as a single agent and in enhancing the antitumor activity of a broad spectrum of chemotherapeutic and anticancer targeted agents. Initial in vivo proof-of-concept of the potential therapeutic benefit of blocking IGF-IR kinase activity in tumor cells was obtained in an orthotopic multiple myeloma (MM) model of bone and bone marrow disease. In this mice model, MM... 

Paclitaxel is a well-established antiproliferative agent with a microtubule-targeting pharmacologic activity (37,42,43). As an anticancer agent, paclitaxel causes polymerization and stabilization of microtubules (43-45). The stabilization of microtubule dynamics by paclitaxel can interrupt many cellular processes, including cell division, migration, activation, maintenance of cytoskeletal framework, and intracellular as well as transmembrane protein transport (42,46,47). 

Keywords Microtubule targeting agents, Molecular docking, Molecular modeling, Pharmacophore, Quantitative structure-activity relationships, Tubulin... 

Joyce, T.H. Self Assembling Activation Agents Targeted Using Active Drug Release with Organic Nanotube or Alpha-DL Peptide Enclosed in Liposomes, 2004-807835 2005214356 (2005). 

Scenario Sources/products Agent/chemical Target population Activity Chemical emission/release from source Exposure pathway Exposure event Exposure route... 

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