Targeted drug delivery applications

Colacino, K.R. Dong, S. Roman, M. Lee, Y.W. Cellulose nanocrystals A novel biomaterial for targeted drug delivery applications. FASEB J. 2011, 25, 762.3. 

FIGURE 54.23 A schematic representation of inverse miniemulsion or microemulsion polymerization for the preparation of nanometer-sized particles of water-soluble and water-swellable polymers as well as cross-linked particles in the presence of cross-linkers. (Reprinted from Polymer, 50(19), Oh, J.K., Bencherif, S.A., and Matyjaszewski, K., Atom transfer radical polymerization in inverse miniemulsion A versatile route toward preparation and functionalization of microgels/nanogels for targeted drug delivery applications, 4407-4423. Copyright 2009, with permission from Elsevier.)... 

Oh, J.K. Bencherif, S.A. Matyjaszewski, K. Atom transfer radical polymerization in inverse miniemulsion A versatile route toward preparation and funetionalization of microgels/nanogels for targeted drug delivery applications. Polymer 2009,50 (19), 4407-4423. 

Another class of environmentally sensitive materials that are being targeted for use in drug delivery applications is thermally sensitive polymers. This type of hydrogel exhibits temperature-sensitive swelling behavior... 

A.L. Klibanov, Microbubble contrast agents Targeted ultrasound imaging and ultra-sound-assisted drug-delivery applications. Invest. Radiol. 41 (2005) 354-362. 

Similar incorporation of ligand-based targeting motifs is applicable to colloidal systems. In the final analysis, the effectiveness of ligand-based targeting drug delivery systems depends on the density of the target receptor on the cell surface, the rate in which the systems are internalized into the cell, and recycling and reexpression of the receptor on the cell surface after internalization. 

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