Target preparation case studies

As another interesting variant on materials with M-C linkages, formally conjugated polymers 210 and 211 have been prepared via polycondensation routes and have been characterized in the solid state.In the case of the intriguing metal-carbyne polymers 211, the materials are fluorescent at room temperature," unlike monomeric species such as (RO)3W=GR (R = alkyl or aryl). Polymers such as 210 and 211 and analogs" represent very exciting targets for future study. 

To illustrate how an effective monomer collection can be created, we will go through a case study. For this purpose, we will consider the Pfizer monomer collection and how it was created. The efforts at Pfizer have largely been focused on creating a monomer collection that facilitates the preparation of target molecules via parallel medicinal chemistry (PMC) approaches in chemically enabled design space the aim of this was to allow the rapid advancement of programs through their discovery cycle. 

The only respect in which the hot atom chemistry of organometallic compounds has so far been applied to other fields of study is in the area of isotope enrichment. Much of this has been done for isolation of radioactive nuclides from other radioactive species for the purpose of nuclear chemical study, or for the preparation of high specific activity radioactive tracers. Some examples of these applications have been given in Table II. The most serious difficulty with preparation of carrier-free tracers by this method is that of radiolysis of the target compound, which can be severe under conditions suited to commercial isotope production, so that the radiolysis products dilute the enriched isotopes. A balance can be struck in some cases, however, between high yield and high specific activity (19, 7J),... 

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