Target preparation

The target preparation and characterisation facilities are shown schematically in Figure 6. Details of typical sample preparation are given in Fang et al [14], Samples... 

Figure 6. Plan of the target preparation facilities consisting of UHV preparation chamber (a), (reactive) ion etching chamber (b), ion etching gun (c), laser (d), photon detector (e), transfer arms (f), Auger system for surface analysis (g), sample manipulator and annealing facility (h), load lock and optical microscope for viewing sample (i), evaporator (j), transmission diffractometer (k), and vacuum tank for main spectrometer (1).

D.C. Lowe and W.J. Judd, Graphite target preparation for radiocarbon dating by accelerator mass spectrometry, Nucl. Instrum. Methods B 28, 113 116 (1987). 

One of the most frequently heard criticisms is that drug targeting preparations cannot be administered orally and are therefore either of secondary or no interest for development into therapeutics. Although significant research effort has been put into the development of oral-... 

The treatment of tumours in the liver with drug targeting preparations is hampered by the lack of tumour specifity of most preparations. Liposomes incorporating the immunomodula-tor muramyl tripeptide phosphatidylethanolamine have been used as an aspecific approach to increasing the number of tumouricidal macrophages in the liver in order to prevent the development of metastases [99].To date, the greatest tumour cell specificity has been obtained... 

In principle, the above-mentioned transport and metabolic functions of the tubule can be used for renal delivery and (re-)activation of (pro-)drugs and macromolecular drug targeting preparations. 

The same may hold true for the different stages in endothelial cell activation during flare-ups in chronic inflammatory disorders. Therefore, the use of a combination of different drug targeting preparations aimed at disease stage-specific epitopes is likely to be a prerequisite for targeting endothelial cells at various stages of activation. 

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