Target preparation resource availability

Why A primary library can be planned for many purposes. Sometimes the project goal is purely academic, that is, simply to open a new combinatorial synthetic route and to report it. This respectable option allows complete freedom to prepare any primary library, with no constraints dictated by parameters such as application, cost, or resources. We will not comment further upon this approach in this section. More often, though, a primary library is prepared as a source of relevant active molecules on various biological targets. This obviously necessitates the availability of several robust and reliable HTS assays for these targets, as well as the synthetic resources, the analytical resources, and the instrumentation to ensure the successful synthesis and analytical characterization of the library. 

An ideal synthesis is generally regarded as one in which the target molecule is prepared from readily available, inexpensive starting materials in one simple, safe, environmentally acceptable, and resource-efficient operation that proceeds quickly and in quantitative yield. ... 

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