Tardive dyskinesia depression with

Rosenbaum, A., Maruta, T., Duane, D., Auger, R., Martin, D., Brenengen, E. (1980). Tardive dyskinesia in depressed patients Successful therapy with antidepressants and lithium. Psychosomatics, 21, 715-719. 

Atypical antipsychotics such as aripiprazole, olanzapine, que-tiapine, risperidone, and ziprasidone are effective as monotherapy or adjunctive therapy with lithium and valproate in the treatment of acute mania. Some antipsychotics have the potential to cause adverse effects such as extrapyramidal reactions, sedation, depression, emotional blunting, sexual dysfunction, weight gain, and orthostatic hypotension. Prophylactic use of antipsychotics may be needed for some patients with recurrent mania or mixed states, but the risks versus benefits must be weighed because of long-term adverse effects (e.g., obesity, type 2 diabetes, hyperlipidemia, hyperprolactinemia, cardiac disease, and tardive dyskinesia). ... 

Rare Hepatic toxicity tinnitus bone marrow depression, including agranulocytosis seizures peripheral neuropathy severe cardiovascular effects in patients with cardiac disease photosensitivity dysarthria smttering withdrawal symptoms nausea, tremor, anorgasmia, and seizures may be more common with clomipramine tardive dyskinesia and neuroleptic malignant syndrome with amoxapine renal failure with overdosage of amoxapine... 

Antipsychotic drugs commonly have been used empirically to manage manic and psychotic illness in bipolar disorder patients. Indeed, standard neuroleptics are a mainstay of the treatment of acute mania (only chlorpromazine is FDA-approved for this indication, although haloperidol has also been widely used) and for manic episodes that break through prophylactic treatment with LF or an anticonvulsant. However, the older antipsychotics are not used routinely for long-term prophylactic treatment in bipolar disorder because their effectiveness is untested, some may worsen depression, and the risk of tardive dyskinesia in these syndromes may be higher than in schizophrenia. 

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