TAP Pharmaceuticals

Cefditoren pivoxil (12 Spectracef TAP Pharmaceuticals, 2001) is an oral prodrug of cefditoren (13), a derivative of cephalosporin isolated from Cephalosporium species. The prodrug is readily hydrolyzed by intestinal esterases to the microbiologically active cephalosporin cefditoren (13)... 

Campbell J. (2007). Dmgs on tap Pharmaceuticals in our drinking water. Pharmacy Practice. Available at http //www.cielap.org/pdf/news.DmgsOnTap.pdf accessed 5/8/2007. 

Prescribing information for Lupron Depot . Manufactured for TAP Pharmaceuticals, Inc., Lake Forest, IL 60045. 

As noted in Chapter 7, Takeda initiated its first venture overseas by forming a ten-year, 50-50 joint venture with Abbott to develop and market new products in 1977 and 1987 its venture was renewed for another ten years. In 1997 TAP Pharmaceuticals became a full-fledged subsidiary of the Japanese company, responsible for the production and marketing organizations for the North American market. In 1998 a comparable subsidiary for Europe was established in Frankfurt, Germany. 

EnTec and Jenapharm synthesized the J compounds which are substituted hydrophobic oximes [9-11]. One of these, J867 or asoprisnil [benzaldehyde-4-[(lip,17P)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11 -yl]-1 -oxime], is now being clinically developed by TAP Pharmaceuticals and Schering (Figure 7.1). 

Asoprisnil (J867) TAP Pharmaceuticals (USA) Schering (Germany) myomas, endometriosis, dysfunctional uterine bleeding... 

The pyridine ring is found in many current pharmaceuticals. It is present in some proton pump inhibitors used for reducing the amount of acid produced by the stomach. These dmgs can be used to treat reflux disease, ulcers, or heartburn. Omeprazole is sold by AstraZeneca Pharmaceuticals LP as the magnesium salt in the racemic form as PRILOSEC and as the S enantiomer as NEXIUM. Lansoprazole is sold by TAP Pharmaceuticals Inc. as PREVACID. Pantoprazole is sold by Wyeth Pharmaceuticals Inc. as the sodium salt under the name PROTONIX. Rabeprazole was developed by Eisai Co. Ltd., who sells it as the sodium salt under the name ACIPHEX. Each of these also contains a benzimidazole ring. 

Prevacid (Lansoprazole delayed-release). Tap Pharmaceutical Inc. US Prescribing information, June 2007. 

The biggest success of pol5mier controlled release systems in cancer therapy however has been in the area of prostate cancer treatment. This therapy is luiique since it uses a hormone-suppressant rather than a chemotherapeutic agent to minimize cancer cell growth in the prostate. Several products include Lupron Depot (TAP Pharmaceuticals), Zoladex (Astra-Zeneca), and Trelstar Depot (Debio RP, Pharmacia). Lupron Depot involves PLA microspheres, Zoladex formulation is an extruded rod, whereas Trelstar depot consists of PLGA microspheres, all of which incorporate LHRH analogues. 

Spectracef orally-active 3rd-generation cephalosporin TAP Pharmaceutical Established... 

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