AstraZeneca pharmaceutical

AstraZeneca Pharmaceuticals 1800 Concord Pike Fairfax Research Center B313 PO Box 15437... 

AstraZeneca Pharmaceuticals Ltd., Process R D, Macclesfield, Cheshire, SK10 2NA, United Kingdom... 

Stephen G. Ryan AstraZeneca Pharmaceuticals, Wilmington, Delaware, U.S. 

Microwave-assisted synthesis is attractive to researchers for many reasons, including speed, yields, and the potential for reduced solvent use. Raman monitoring offers a convenient way to elucidate the chemical mechanism while instantly, continuously monitoring reaction kinetics. This enables rapid, data-driven process optimizations without concerns about safely and accurately sampling out of a microwave vessel stopped mid-reaction. Pivonka and Empheld of AstraZeneca Pharmaceuticals describe the continuous acquisition of Raman spectra of an amine or Knoevenagel coupling reaction in a sealed microwave reaction vessel at elevated temperatures and pressures [134]. 

AstraZeneca Pharmaceuticals Mereside 3S111, SK 10 4TG Macclesfield, Cheshire United Kingdom... 

Carl B. Rilino AstraZeneca Pharmaceuticals LP, Newark, Delaware, U.S.A. 

Figure 1 Validation of new processes. (Courtesy of AstraZeneca Pharmaceuticals LP, Wilmington, Delaware.)... 

Pivonka and Empfield of AstraZeneca Pharmaceuticals describe the continuous acquisition of Raman spectra of an amine or Knoevenagel coupling reaction in a sealed micro-wave reaction vessel at elevated temperatures and pressures.57 A microwave synthesizer was modified to accommodate a non-contact Raman probe. This approach helps... 

AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, UK... 

Jeffrey S. Albert CNS Discovery Research, AstraZeneca Pharmaceuticals, 1800 Concord Pike, P.O. Box 15437, Wilmington, DE 19850-5437, USA... 

Debra Henn holds a Doctor of Pharmacy degree from the University of the Sciences in Philadelphia, Philadelphia College of Pharmacy. She completed a post-doctoral specialty residency in drug information at Thomas Jefferson University Hospital in Philadelphia and Bristol-Myers Squibb Company, Plainsboro New Jersey. Dr. Henn is currently employed as a Medical Information Manager at AstraZeneca Pharmaceuticals in Wilmington, Delaware. 

AstraZeneca Pharmaceuticals LP Sero-quel. Rev. 01/01. http //www.fda.gov/ cder/foi/label/2001/20639slllbl.pdf (accessed February 14, 2005). 

AstraZeneca Pharmaceuticals Wilmington, Delaware debra.banville astrazeneca.com... 

William F. Michne AstraZeneca Pharmaceuticals Department of Chemistry 1800 Concord Pike Wilmingtion, DE 19850-5437 USA... 

Paul Hueseman, PharmD, Medical Information Scientist, National Accounts, AstraZeneca Pharmaceuticals, and Ben Sloan, National Account Director, Salix Pharmaceuticals. 

Nolvadex (tamoxifen) product information. AstraZeneca Pharmaceuticals LP, June 2003. 

Another example of an EGER (HERl receptor) inhibitor is gefitinib (Iressa AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA). In May 2003, gefitinib (ZD1839) received accelerated approval by the US Food and Drug Administration as monotherapy for patients with locally advanced or metastatic non-smaU cell lung cancer (NSCLC), after failure of both platinum-based and docetaxel chemotherapies. 

Faslodex (fulvestrant injection). Prescribing Information. AstraZeneca Pharmaceuticals, 2004. 

Bennett, G. Lee, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA. Current address AstraZeneca Pharmaceuticals, Wilmington, DE 19803, USA. 

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