Green Cross Corporation

The authors wish to thank the Green Cross Corporation, Taisho Pharmaceutical Co.,... 

The Green Cross Corporation, who have also been very active in the field of artificial blood substitutes, have synthesised a wide range of potential materials stemming from their first practical product Fluosol-DA, a mixture of perfluo-rodecalin and perfluorotripropylamine. 

Some researchers are exploring a totally different approach to the production of artificial blood that focuses on the synthesis of nonnatural substances with bloodlike properties. This approach has the advantage of avoiding the use of human or animal blood or any of its components. One line of research makes use of a class of chemicals known as the perfluorocarbons (PFCs), hydrocarbons in which all hydrogens have been replaced by fluorine atoms. The first PFC to be marketed commercially was called Fluosol-DA, manufactured by the Green Cross Corporation of Japan. Fluosol-DA was a mixture of perfluorodecalin (C10F18) and perfluorotripropylamine (CgF21N) emulsified with Pluronic F-68, a copolymer of oxyethylene and oxy-propylene. 

The first successful development of an injectable perfluorocarbon-based commercial product was achieved by the Green Cross Corporation in Japan, when it made Fluosol-DA , a dilute (20 /o w/v) emulsion based on perfluorodecalin and perflurotripropylamine emulsified... 

The first-generation oxygen carriers Fluosol-DA and Fluosol 43 are fluorochemical emulsions manufactured by the Green Cross Corporation in Japan. Ftorosan has been made in the Soviet Union (replaced by Perftoran), and Emulsion No. 2 in China. 

More than a dozen companies had signed up as of December 1981. They Include Ell Lilly and Company, Schering-Plough, Smlth-Kline Corporation, DuPont Company, International Minerals and Chemical, Advanced Genetic Sciences, and Japan s Green Cross. Several dozen more companies are expected to sign up in the near future. 

FIGURE 13.5 Analysis of the DR data for a compound class or complete hit set. It can be easily analyzed which other assays overlap with the given hits. The color coding is from green (inactive) to dark red (very active) compounds. Reprinted from Bioorganic Medicinal Chemistry, Vol. 20, Bernd Beck, BioProfile—Extract knowledge from corporate databases to assess cross-reactivities of compounds, 5428-5435,2012, with permission from Elsevier. For color details, please see color plate section. 

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