Tailoring reactions

In the partial oxidation of methane to yield liquid products, it is desirable to tailor reaction conditions to minimize further oxidation of formaldehyde. However, as mentioned in Chapter 13, this is difficult. A number of reactions may consume formaldehyde, including (R20), (R24), and... 

To conclude The functional anion concept opens up ne v possibilities to tailor reaction enthalpies of high capacity hydrides to vards potential applications. At present, ho vever, not much is known about how successful this method will eventually be and which material classes can be successfully altered by it. 

Approaches to ultradeep HDS include (a) improving catalytic activity by new catalyst formulation for HDS of 4,6-DMDBT, (b) tailoring reaction and process conditions, and (c) designing new reactor configurations. Design approaches for ultradeep HDS focus on how to remove 4,6-DMDBT in gas oil more effectively. One or more approaches may be employed by a refinery to meet the challenges of producing ultraclean fuels at affordable cost. 

Dissection of New NRPS Enzymology and of Deviations from NRPS Colinearity Characterization of Tailoring Reactions Characterization of Multistage Assembly Line Action Time Courses... 

Since most current papers that are published on NRPS systems utilize some form of MS, we have divided the application of MS methods to understand NRPS pathways into five different categories (1) investigation of substrate specificity in NRPS systems, (2) characterization of new NRPS enzymology and of deviations from colinearity, (3) characterization of tailoring reactions, (4) characterization of multistage assembly line action, and (5) time courses. 

MS-based substrate identification assays of tailoring enzymes depend on whether the biosynthetic substrate is T domain bound or not. If the biosynthetic substrate is T domain bound, the predicted native substrate is loaded on the T domain and the mass change upon the tailoring reaction is detected by ESI—FTMS. If the biosynthetic substrate is non-T domain bound, conversion of the predicted native substrate by tailoring reaction can be detected by low-resolution MS. Biosynthetic substrate tolerance assays for tailoring enzymes are conducted in a one-assay-one-substrate approach like substrate identification assays but with alternative biosynthetic substrates. 

Recently, two new tailoring reactions were analyzed using MS.55 107 Other NRP tailoring mechanisms that have been characterized by utilization of MS and protein crystallography have been reviewed elsewhere4 11... 

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