Tacrolimus Cimetidine

Drugs that affect all phosphodiesterase type 5 inhibitors include the following alcohol, amlodipine, angiotensin II receptor blockers, antacids, bendroflumethiazide, beta blockers, cimetidine, diuretics, enalaphl, metoprolol, nifedipine, rifampin, tacrolimus. 

Drugs that may affect fluconazole include cimetidine, hydrochlorothiazide, and rifampin. Drugs that may be affected by fluconazole include alfentanil, benzodiazepines, buspirone, carbamazepine, cisapride, oral contraceptives, corticosteroids, cyclosporine, haloperidol, HMG-CoA reductase inhibitors, losartan, nisoldipine, phenytoin, protease inhibitors, rifabutin, sirolimus, sulfonylureas, tacrolimus, theophylline, tolterodine, tricyclic antidepressants, vinca alkaloids, warfarin, zidovudine, and zolpidem. 

Drugs that may affect tacrolimus include nephrotoxic agents (aminoglycosides, amphotericin B, cisplatin, cyclosporine), antifungals, bromocriptine, calcium channel blockers, cimetidine, clarithromycin, danazol, diltiazem, erythromycin, methylprednisolone, metoclopramide, carbamazepine, phenobarbital, phenytoin, rifamycins, cisapride, chloramphenicol, metronidazole, nefazodone, omeprazole, protease inhibitors, macrolide antibiotics, fosphenytoin, and St. John s wort. 

There are drug products whose interaction with PVC bags and infusion sets are so high that they must include labehng precautions for use with PVC containers. These drugs include antineoplastics such as pachtaxel, docetaxel, tacrolimus, and teniposide, and others such as ciprofloxacin, cefoperazone sodium, fluconazole, metronidazole HC1, cimetidine, and propofol [64,65]. 

Ku, Y.-M. Min, D.I. Kumar, V. Noormohamed, S.E. Compatibility of tacrolimus injection with cimetidine hydrochloride injection in 0.9% sodium chloride injection. Am.J.Health-Syst.Pharm., 1995, 52, 2024-2025... 

A4 Amiodarone, azole antifungals, cimetidine, clarithromycin, cyclosporine, erythromycin, fluoroquinolones, grapefruit juice, HIV protease inhibitors, metronidazole, quinine. SSRIs, tacrolimus Antiarrhythmics, antidepressants, azole antifungals, benzodiazepines, calcium channel blockers, cyclosporine, delavirdine, doxorubicin, efavirenz, erythromycin, estrogens, HIV protease inhibitors, nefazodone. paclitaxel, proton pump inhibitors, HMG-CoA reductase inhibitors, rifabutin, rifampin, sildenafil, SSRIs, tamoxifen, trazodone, vinca anticancer agents... 

A study in 51 kidney transplant patients taking tacrolimus and omeprazole 20 mg daily found no significant interaction. A retrospective study in 48 kidney transplant patients found that when patients switched from cimetidine 400 mg daily to omeprazole 20 mg daily resulted in a 15% decrease in the dose/weight normalised tacrolimus trough levels. ... 

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