Tablet press instrumentation manufacturing

Tablet Evaluation Using Near-Infrared Spectroscopy / 3630 Tablet Formulation / 3641 Tablet Manufacture / 3653 Tablet Manufacture by Direct Compression / 3673 Tablet Press Instrumentation / 3684 Tablet Testing / 3707 Technology Transfer Considerations tor Pharmaceuticals / 3717...

A major development in pharmaceutical technology has been the application of instrumentation techniques to tablet presses. The ability to monitor the forces that develop during the compaction, ejection, and detachment of tablets has brought about new insights into the physics of compaction, facilitated formulation development, and provided a means for the in-process control of tablet weight in manufacturing [62,63], In... 

Instrumented tablet presses with computer interfaces allow the pharmaceutical scientist to study the mechanism of compaction and the relationship of the mechanism to tablet-compaction properties and formulations. In addition, automated systems are useful to develop compression profiles for reference purposes, to control weight of tablets during development and production, and to monitor punch wear. This automation reduces the burden on personnel faced with the requirements of quality control. Merck Sharp and Dohme s major production facility in the United Kingdom is fully computerized to manufacture a high-volume tablet product as well as multiple-tablet products. " ... 

Pharmaceutical products have been manufactured into compressed tablets for many years. During the 1950s, much research was devoted to the physics of compression.f Since that time, the pharmaceutical industry has attained a much greater understanding of the compression process, which resulted in the development of more robust pharmaceutical formula-tions. This has been achieved by the use of instrumented tablet presses and sophisticated data collection systems combined with the development of mathematical models. 

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