Tablet formulation acetaminophen

Fig. 3 (a) The XRD pattern of acetaminophen powder, (b) The XRD pattern of aspirin powder, (c) The XRD pattern of caffeine powder, (d) The XRD pattern of a powdered tablet formulation containing acetaminophen, aspirin, and caffeine (Excedrin ). (From Ref... 

Cao Q. Choi YW, Cui JH, Lee BJ. Formulation, release characteristics and bioavailability of novel monolithic hydroxypropylmethylcellulose matrix tablets containing acetaminophen. J Control Rel 2005 I08(2-3) 35I-6I. 

Wallo, W.E. D Adamo, A. Simultaneous assay of hydrocodone bitartrate and acetaminophen in a tablet formulation. J.Pharm.Sci., 1982, 71, 1115-1118... 

Alvi, S.U. Castro, F. A stability-indicating simultaneous analysis of acetaminophen and hydrocodone bitartrate in tablets formulation by HPLC. J.Liq.Chromatogr., 1987, 10, 3413-3426 [stability-indicating simultaneous codeine, hydrocodone hydromorphone tablets column temp 30]... 

Most of the oxycodone drugs—which include the drug alone or in combination with aspirin or acetaminophen—are available in tablet form. For patients who have trouble swallowing or who cannot take the tablet form for other reasons, the drug is available in a highly concentrated flavored liquid solution. The appropriate dose of the liquid is measured into a dropper either by a nurse or by the patient. Often, the liquid may be added to semi-soft foods such as applesauce or pudding to help disguise its bitter taste. Those who use liquid formulations of oxycodone should be aware that some of them may contain alcohol. 

It is normally difficult to produce tablets with ascorbic acid by direct compression, but as is shown in Table 174, they can be produced much more readily using copovidone. When this dry binder is added, the hardness of the tablets increases and the friability decreases much more than after the addition of povidone K 30 or hydroxypropylmethylcellulose (HPMC) which had no effect on the hardness in this formulation. Similar results were shown in Fig. 111 for acetaminophen tablets. 

Many analgesic effectiveness studies involving combination drug formulations (an opioid combined with a nonopioid) have been reported. For example, in the treatment of moderate to severe postoperative obstetric or gynecologic pain, 2-tablet dose of hydrocodone 7.5 mg with ibuprofen 200 mg was comparable in efficacy to the 2-tablet dose of oxycodone 5 mg and acetaminophen 325 mg. Obviously both of these treatments were superior to the placebo [23]. In contrast, for treatment of chronic pain, the 2-tablet dose of hydrocodone 7.5 mg and ibuprofen 200 mg was more effective than either the 1 -tablet dose of this combination or the 2-tablet dose of codeine 30 mg and acetaminophen 300 mg combination [24]. In a double-blind, randomized controlled trial involving 118 patients with chronic cancer pain, the combination formulation of hydrocodone (25 mg/d) and acetaminophen (2500 mg/d) was effective in relieving pain in 56.5% of the patients [25]. 

In humans, exposure to paracetamol (acetaminophen) is primarily by the oral route from a wide variety of formulations (tablets, capsules and liquids) either on its own or in combination with other drugs. An estimate of paracetamol (acetaminophen) consumption [prescribed paracetamol (acetaminophen), combination tablets and paracetamol (acetaminophen) without a prescription] was 3500 million 500 mg tablets in the year 2000 The acute toxicity of paracetamol (acetaminophen) in man and experimental animals is due to its dose-dependent metabolic profile. 

Thomas, B.R. Fang, X.G. Shen, R Ghodbane, S. Mixed ion pair liquid chromatography method for the simultaneous assay of ascorbic acid, caffeine, chlorpheniramine maleate, dextromethorphan HBr monohydrate and paracetamol in Frenadol sachets. J.Pharm.Biomed.Anal., 1994,12, 85-90 [simultaneous caffeine, chlorpheniramine, dextromethorphan, vitamin C formulations] van der Veen, J. Eissens, A.C. Lerk, C.F. Controlled release of paracetamol from amylodextrin tablets In vitro and in vivo results. Pharm.Res., 1994, 11, 384-387 [plasma pharmacokinetics] Abounassif, M.A. Abdel-Moety, E.M. Gad-Kariem, R.A. HPLC-quantification of diethylamine saliqylate and methyl nicotinate in ointments. J.Liq.Chromatogn, 1992,15, 625-636 [formulations ointments simultabeous diethylamine salicylate, methyl nicotinate acetaminophen is IS simultaneous methyl paraben, propyl paraben... 

Proprietary Names (1) combined with acetaminophen (multiple different preparations in tablet, capsule, and elixir form) Vicodin , Lortab , Norco , and numerous generic formulations (2) combined with aspirin or ibuprofen Damason-P , Vicoprofen ... 

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