T-cell responses and

Capobianco F. Butteroni C. Barletta B. Corinti S, Afferni C. Tinghino R. Boirivant M, Di Felice G Oral sensitization with shrimp tropomyosin induces in mice allergen-specific IgE. T-cell response and systemic anaphylactic reactions. Int Immunol 2008 20 1077-1086. 

HIV produces profound CD4 depletion, possibly through initial massive depletion of gut-associated memory T-cells, followed by chronic immune activation, leading to fatigue of homeostatic T-cell responses and progressive immunodeficiency (McArthur et al. 2005). 

The activation of a T-cell response and subsequent efficacy of DNA vaccines is ultimately determined by professional antigen presenting cells, such as macrophages, dendritic cells, and Langerhans cells (Corr et al., 1996 Doe et al., 1996 Iwasaki et al., 1997 Ulmer et al., 1996). It follows that successful DNA vaccination strategies should seek to target DNA... 

Groux, H. et al., A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature 389,737-742, 1997. 

Some additional subunit vaccines are being developed, based upon internal viral polypeptides, particularly the p24 core protein. This was chosen as it is known to contain epitopes capable of eliciting a T cell response, and core proteins are generally less subject to antigenic drift than envelope proteins. 

Fridkis-Hareli, M., Santambrogio, L., Stern, J.N., Fugger, L Brosnan, C., and Strominger, J.L. (2002) Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis. J. Clin. Invest. 109, 1635-1643. 

Ma J, Urba WJ, Si L, Wang Y, Fox BA, Hu HM (2003) And-tumor T cell response and protecdve immunity in mice diat received subledial iiTadiadon and immune reconsdtudon. Eur J Immunol 33 2123-2132. 

Cytotoxic T cell response and IFN- y production after subcutaneous immunization with NS1851 peptide... 

Paradoxically, however, this cytokine appears equally important in limiting T cell responses and eliminating autoreactive T cells. Prolonged or repeated activation in the presence of IL-2 causes T-ceU apoptosis and mutations that inactive IL-2 or its receptor lead to excessive T-cell proliferation and autoimmunity. IL-2 is thus a two-edged sword that initiates immune responses but also limits their intensity and duration. 

CDS " T cell responses and levels of protection compared with intramuscular injection. 

Ko, S., Yip, H.-K., Zhen, Y.-Y., et al., 2015. Adipose-derived mesenchymal stem cell exosomes suppress hepatocellular carcinoma growth in a rat model apparent diffusion coefficient, natural killer T-cell responses, and histopathological features. Stem Cells Int. 2015, Article ID 853506. 

Schonemeyer A, Lucius R, Sonnenburg B et al. Modulation of human T-cell responses and macrophage functions by Onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus. J Immunol 2001 167 3207-3215. 

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