T-cell determinants

Shih, F.F., Cerasoli, D.M., and Caton, A.J. (1997) A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice. Int. Immunol. 9,249-261. 

Maeji NJ, Bray AM, Geysen HM (1990) Multi-pin peptide synthesis strategy for T cell determinant analysis, J Immunol Methods 134 23-33. 

Immunophenotypic markers of monoclonal T-cell proliferations have not been identified. However, subtle alterations in broadly active T-cell selective ( pan-T-cell ) determinants may be helpful in selected cases. Cutaneous T-cell lymphomas (CTCL) characteristically express aberrant phenotypes, represented either by the relative absence of the pan-T-cell markers CD3, CDS, CD43, and CD7 (especially the last of those) or by the concordant expression or loss of both CD4 and CDS (Fig. 13.19).i 454 xhose results are not expected in most mature reactive (benign) T-cell populations. 455,156 Unfortunately, some examples of CTCL fail to exhibit aberrant phenotypes, limiting the value of these attributes in the separation of such lymphomas from T-cell-rich dermatitides,i 455 and, conversely,... 

If it is available, frozen tissue can be studied immu-nohistologically to assess the presence or absence of an aberrant T-cell phenotype. The latter is said to be defined by the loss of one or more pan-T-cell determinants (CD2, 3, 5, and 7), as mentioned earlier, or by the coexpression of antigens that are usually mutually exclusive (e.g., both CD4 and CDS in the same cell population). 466 CD7 is the pan-T-cell antigen cluster... 

Tscharke DC, Karupiah G, Zhou J et al 2005 Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med 201 95-104... 

Demotz, S., Grey, H., Appeiia, E., and Sette, A. (1989) Characterization of a naturally processed MHC class II restricted T-cell determinant of hen egg lysozyme. Nature 342, 682-684. 

Francis, M. J., Hastings, G. Z., Syred, A. D., McGinn, B., Brown, F., Rowlands, D. J., 1987, Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants. Nature 330 168-70. 

Jackson, D. C., Fitzmaurice, C. J., Sheppard, R. C., McMurray, J., Brown, L. E., 1995, The antigenic and immunogenic properties of synthetic peptide-based T-cell determinant polymers. BiomedPep Prot andNuclAcids 1 171-176. 

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