Systemic effects swallowing

When used topically in prescribed doses, there are usually minimal systemic effects in most individuals. On occasion, nasal burning, stinging, and dryness may be seen. When the topical form is used frequently or if the liquid is swallowed, the same adverse reactions seen with the oral decongestants may occur. 

If spilled on the skin or in the eyes liquid N2IL, can cause severe local damage or burns and can cause dermatitis. In addition it can penetrate skin to cause systemic effects similar to those produced when the compound is swallowed or inhaled. Inhalation of the vapor causes local irritation of the respiratory tract and eyes. On short exposure systemic effects involve the central nervous system. Resultant symptoms include tremors, on exposure to higher concentrations, convulsions and possibly death follow. Repeated exposures may cause toxic damage to the liver (fatty liver) and kidney (interstitial nephritis), as well as anemia. The threshold limit value of hydrazine is 1 ppm (1.3 mg/m3)(Ref 20) (See also Refs 27 c and 33a)... 

Flunisolide. The portion of a Bunisolide (AetoBid, Nasarel) dose that is. swallowed is rapidly converted to the 6/3-hydroxy metabolite after first-pass metabolism in the liver. Tlie 6/ hydroxy metabolite is approximately as active as hydrocortisone itself, but the small amount produced usually has limited systemic effects. Water-soluble conjugates are inactive. 

Chlorzoxazone is harmful if swallowed, inhaled, or absorbed through skin. It causes drowsiness central nervous system effects such as headache, dizziness, and blurred vision nausea and vomiting and eye, skin, and mucous membrane irritation. The target organs are the liver, nerves, and skeletal muscles. Although morbidity and mortality are low in pure compound ingestion, they may be increased in multiple ingestions. 

Rectal (PR) Absorption may vary from suppository. More reliable absorption from enema (.solution). Useful when patient cannot swallow medication. Used for local and systemic effects. Absorption may be erratic. Suppository may migrate to different position. Some patient discomfort. 

Inhalation Rapid absorption. Total dose absorbed is variable. May be used for local or systemic effects. Particle size of drug determines anatomic placement in respiratory tract. May stimulate cough reflex. Some drug may be swallowed. 

Precautions A poison central nervous system effects by swallowing. Other routes of consumption result in hallucinations, distorted perceptions, possible cardiac failure, and convulsions. An eye irritant. An abused controlled substance. Use leads to addiction and habit. 

Precautions Mildly toxic by swallowing large amounts. Humans sustain central nervous system effects at low doses. A skin irritant. FDA approves use at modest levels to accomplish the intended... 

Precautions Moderately toxic by swallowing. Effects by breathing are lachrymation, (watering eyes), respiratory obstruction, and other unspecified respiratory system effects. An eye irritant. Narcotic in high concentrations. 

Absorption route Can enter the body by inhalation or ingestioa Harmful atmospheric concentrations build up fairly slowly on evap tion at 20 C. but much more rapidly in aerosol form. Immediate effects Irritates the qresand respiratory tract Liquid destroys the kin s natural o8s. Affects the nervous system. If swallowed can impair fee visioa ... 

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