Systemic considerations lymphatics

J. G. Hall, The lymphatic system in drug targeting An overview, in Targeting of Drugs. Anatomical and Physiological Considerations (G. Gregoriadis and G. Poste, eds.), Plenum Press, New York, 1985, p. 15. 

Hall JG. The lymphatic system in drug targeting an overview. In Gregoriadis G, Poste G, eds. Targeting of Drugs—Anatomical and Physiological Considerations. New York Plenum Press, 1985 15. 

Encouraged by this success, he carried out the same operation on a second woman whose case seemed even more hopeless. She was 40 years of age and reported that she had first noticed the growth in her right breast about five years earlier. At the time Beatson first saw her, the tumour extended over much of the breast and there were numerous small tumour masses under her arms and in her neck. Clearly, the cancer had metastasized via the lymphatic system to these various lymph nodes, and she was in considerable pain. She had already been refused treatment at two other local infirmaries on the... 

Pharmacologically, the action of the various bacterial toxins is specific for each individual toxin. In the case of botulinus and tetanus toxins, action seems to be restricted to brain or nerve tissue. Bishop and Bronfenbrenner (11) state that botulinus toxin has a curare-like action and that the toxin is specific for the myoneural jimctions. Death in animals is due to respiratory paralysis. By means of artificial respiration, these authors and more recently Legroux and Levaditi (79) have been able to prolong the life of intoxicated animals for a considerable length of time. The pharmacological action of tetanus toxin is still a controversial question. Two main hypotheses have been summarized by Topley and Wilson (135) as follows (I) That the toxin is absorbed by the motor nerve endings and carried up the axis cylinders to the anterior horn cells of the central nervous system, which are then stimulated to produce muscular contractions and 2) that the toxin acts locally on the motor nerve endings and centrally on the anterior horn cells, which it reaches via the lymphatic vessels and the blood stream. ... 

The following considerations suggest that many biological systems may be affected by differential flow instabilities DIFI. First, differential flows occur naturally, for instance in the circulatory, digestive and lymphatic systems where a flow containing one key species may interact with a counteracting species that is bound to the wall of the vessel. In vitro, cells or enzymes may be readily immobilized on appropriate supports for experiments in a flow system similar to the one shown in Figure 8. 

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