Systematic lupus erythematosus

In the autoimmune diseases scleroderma and systematic lupus erythematosus antigens to nuclear proteins or nucleic acids are present in the blood. 

Giant cell arteritis Systematic lupus erythematosus Antiphospholipid antibody syndrome... 

Monocytosis (>800/mm of blood) occurs with some infections (e.g., tuberculosis, histoplasmosis, toxoplasmosis, bacterial endocarditis, and salmonellosis), collagen vascular diseases (rheumatoid arthritis and systematic lupus erythematosus), gastrointestinal disorders (ulcerative cohtis and alcoholic liver disease), leukemias, and up to 60% of nonhematologic malignancies, whereas abnormally low monocyte concentrations occur in patients with hairy cell leukemia or aplastic anemia." ... 

Change, E., Abrahamowicz, M., Ferland, D., and Fortin, P.R. (2002) Comparison of the Responsiveness of Lupus Disease Activity Measures to Changes in Systematic Lupus Erythematosus Activity Relevant to Patients and Physicians, 7. Clin. Epidemiol. 55,488-497. 

KaUick, C. A. Specific bacterial inclusions in bone marrow cells indicate systematic lupus erythematosus, and treatment for lupus. U.S. Pat. 

Numerous case reports have suggested that combined oral contraceptives can cause systemic lupus erythematosus (148,278). However, systematic examination of this issue in a 1994 case-control study showed no association (279). 

Systemic lupus erythematosus (SLE) is multisystem autoimmune disease characterized by the production of autoantibodies against a host of nuclear antigens. Lupus, the Latin word for wolf, has been used for at least seven centuries to describe the malar rash that some think resembles an animal bite. The disease was recogifized initially as a skin disease. Hebra and Kaposi were the first to report systemic involvement of the disease. Their work published in 1874 described the association of lupus with anemia, lung involvement, mental status changes, and death. In three papers published between 1895 and 1903, Sir William Osier described the systematic involvement of lupus, the first detailed description recogifizing the multiple systems affected by the disease. 

Ramos-Casals M, Soto MJ, Cuadrado Ml, Khamashta MA. Rituximab in systemic lupus erythematosus a systematic review of off-label use in 188 cases. Lupus 2009 18(9) 767-76. 

---