Synthetic polymers dosages

Lehmann K, Dreher D. The use of aqueous synthetic-polymer dispersions for coating pharmaceutical dosage forms. Drugs Made Ger 1973 16 126, 131, 132, 134, 136. 

Various natural, semisynthetic, and synthetic polymers are in use as the structural backbone for both controlled release and conventional drug delivery systems (Table 1). Pol5uners selected in the preparation of the dosage form must comply with the following requirements ... 

Polymers are widely used as excipients in dosage forms. As excipients, they should exhibit some properties such as being compatible, nontoxic, stable and cost effective. They can be classified as natural and synthetic polymers [3]. Today there is an... 

Fig. 11.2 Examples of natural, semi-synthetic and synthetic polymers used to prepare drug dosage forms...

Table 11.3 Synthetic polymers commonly used as film-forming agents for coating of solid dosage forms. Data taken from references [8, 34]...

Polydioxanone (PDS) is completely elirninated from the body upon absorption. The mechanism of polydioxanone degradation is similar to that observed for other synthetic bioabsorbable polymers. Polydioxanone degradation in vitro was affected by gamma irradiation dosage but not substantially by the presence of enzymes (39). The strength loss and absorption of braided PDS, but not monofilament PDS, implanted in infected wounds, however, was significantly greater than in noninfected wounds. 

Add bentonite, alum, and anionic polymer to the synthetic wash water. The dosage was 2 L of powdered bentonite clay, 100 ml of 10 N N OH, 20 ml of 57% alum solution and 25 ml of anionic polymer. 

Control over DNA delivery can be achieved by the formation of both synthetic and natural polymers in a variety of dosage forms such as matrix, reservoir, nano/microparticles. 

Since the dissolution of polymeric materials is the key to this mechanism, the polymers used must be water-soluble and/or degradable in water. The choice of a particular polymer for a particular controlled release dosage form depends on various factors such as the dissolution mechanism, delivery period, delivery route, the drag etc. In general, synthetic water-soluble polymers tend to be widely used for oral-controlled release dosage forms. Biodegradable polymers tend to be used for injectable, or implantable, drag delivery systems. 

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