Conventional drug delivery systems

Fig. 1 Drug concentration profiles in the systemic circulation as a result of taking a series of multiple doses of a conventional drug-delivery system (Ai, A2,. ..) in comparison with the ideal drug concentration profile (B). (Adapted from...

The controlled-release drug delivery systems outlined here have been steadily introduced into the biomedical community since the middle of the 1970s. There is a growing belief that many more of the conventional drug delivery systems we have been using for decades will be gradually replaced in the coming years by these CrDDSs. 

Topical delivery systems are intended to deliver the medicaments to body surface such as the skin or the mucus membrane. These systems minimize the problems associated with the conventional drug delivery systems. Hence, the delivery route may be used as an alternative... 

The use of hydrophilic polymers in the development of controlled release formulations for the delivery of drugs for oral route has proven to be advantageous over conventional drug delivery systems. Polymeric delivery systems have the... 

Various natural, semisynthetic, and synthetic polymers are in use as the structural backbone for both controlled release and conventional drug delivery systems (Table 1). Pol5uners selected in the preparation of the dosage form must comply with the following requirements ... 

In order to address some important bottlenecks of conventional drug-delivery systems, this chapter section represents a collaborative effort to explore the mechanism and attempt to find a molecular-based solution for relief, cure or control for several negative consequences of xmcontrolled free radical damage at the molecular level, which is still relevant in biological systems, and more specifically, in the disease states (e.g., oral mucositis and cancer). 

---