Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Synthetic methods ring opening

The synthesis of pyrylium salts, discovered in a classical study by Dilthey (20JPR(l0l)l77>, involves the facile acid-catalyzed cyclization of a 1,5-dicarbonyl compound. The value of this route stems from the different structural features which are acceptable in the five-carbon unit and from the variety of methods available for their synthesis. The reaction is the reverse of the synthetically useful ring opening of pyrylium salts by nucleophiles. [Pg.861]

When a mixture of alkenes 1 and 2 or an unsymmetrically substituted alkene 3 is treated with an appropriate transition-metal catalyst, a mixture of products (including fi/Z-isomers) from apparent interchange of alkylidene moieties is obtained by a process called alkene metathesis. With the development of new catalysts in recent years, alkene metathesis has become a useful synthetic method. Special synthetic applications are, for example, ring-closing metathesis (RCM) and ring-opening metathesis polymerization (ROM) (see below). [Pg.10]

Thiirane oxides (3 x = 1) were rather rare and not well characterized until about 20 years ago20. Since 1965 synthetic methods for their preparation have been consistently and systematically explored2. They are rather thermodynamically stable compounds— compared to their closely-related thiirane dioxides—provided they have an anticonfiguration with respect to the substituents and the sulfinyl oxygen. Also they are more resistant than the corresponding sulfones toward ring opening by either nucleophiles or electrophiles. [Pg.384]

Synthetic work commenced with evaluation of an azomethine ylide dipole for the proposed intramolecular dipolar cycloaddition. A number of methods exist for the preparation of azomethine ylides, including, inter alia, transformations based on fluoride-mediated desilylation of a-silyliminium species, electrocyclic ring opening of aziridines, and tautomerization of a-amino acid ester imines [37]. In particular, the fluoride-mediated desilylation of a-silyliminium species, first reported by Vedejs in 1979 [38], is among the most widely used methods for the generation of non-stabilized azomethine ylides (Scheme 1.6). [Pg.9]

Fig. 7 Synthesis of heterobifunctional PEG. (a) Nagasaki et al. developed a method for the polymerization of EO using an initiator containing defined functionalities [16, 17]. (b) Akiyama et al. further developed a synthetic route to prepare a series of heterobifunctional PEGs [18-21]. After the ring-opening polymerization of ethylene oxide, a second functional group was introduced at the co-end of PEG... Fig. 7 Synthesis of heterobifunctional PEG. (a) Nagasaki et al. developed a method for the polymerization of EO using an initiator containing defined functionalities [16, 17]. (b) Akiyama et al. further developed a synthetic route to prepare a series of heterobifunctional PEGs [18-21]. After the ring-opening polymerization of ethylene oxide, a second functional group was introduced at the co-end of PEG...
Cyclic method, selenium and tellurium purification via, 22 86 Cyclic molecules, synthetic, 24 35 Cyclic monomers, ring-opening polymerization of, 14 271 Cyclic monoterpenes, aroma chemicals,... [Pg.241]

In connection with the synthetic work directed towards the total synthesis of polyene macrolide antibiotics -such as amphotericin B (i)- Sharpless and Masamune [1] on one hand, and Nicolaou and Uenishi on the other [2], have developed alternative methods for the enantioselective synthesis of 1,3-diols and, in general, 1, 3, 5...(2n + 1) polyols. One of these methods is based on the Sharpless asymmetric epoxidation of allylic alcohols [3] and regioselective reductive ring opening of epoxides by metal hydrides, such as Red-Al and DIBAL. The second method uses available monosaccharides from the "chiral pool" [4], such as D-glucose. [Pg.386]

Lactonization of the suitable hydroxy acids or their derivatives is the most common synthetic method for benzoxepinenones with fused pyrrole rings. Therefore, reduction of the formyl group in the ester aldehyde 121 with sodium borohydride gives a mixture of alcohol 122 (80% yield) and lactone 123 (19%). Further heating of the open-chain product 122 in refluxing ethanol affords cyclic lactone 123 quantitatively (Scheme 25 (1998T11079)). [Pg.21]

Various EADIs have been synthesized using different synthetic routes [30-34], One of the widely used methods of preparation of E-alkene peptide bond isosteres involving ring opening of vinyl aziridines by cuprates has recently been reviewed [35,36],... [Pg.703]

Amino acids have been used as nucleophiles to effect the ring opening of saturated 5(477)-oxazolones 253 as a coupling method in an attempt to describe a general procedure for peptide synthesis (Scheme 7.82). However, the problems arising from racemization, that is, when a proton is present at C-4 of the oxazolone, render this procedure of limited synthetic utility. [Pg.185]


See other pages where Synthetic methods ring opening is mentioned: [Pg.839]    [Pg.839]    [Pg.188]    [Pg.188]    [Pg.601]    [Pg.188]    [Pg.299]    [Pg.208]    [Pg.14]    [Pg.3]    [Pg.250]    [Pg.289]    [Pg.52]    [Pg.182]    [Pg.63]    [Pg.283]    [Pg.52]    [Pg.173]    [Pg.297]    [Pg.111]    [Pg.557]    [Pg.281]    [Pg.467]    [Pg.4]    [Pg.37]    [Pg.140]    [Pg.301]    [Pg.28]    [Pg.477]    [Pg.250]    [Pg.14]    [Pg.81]    [Pg.478]    [Pg.82]    [Pg.95]    [Pg.959]   
See also in sourсe #XX -- [ Pg.81 , Pg.87 , Pg.88 , Pg.89 , Pg.136 , Pg.206 ]

See also in sourсe #XX -- [ Pg.81 , Pg.87 , Pg.88 , Pg.89 , Pg.136 , Pg.206 ]




SEARCH



Ring method

© 2024 chempedia.info