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Synergistic action with tumor

Given the encouraging safety and therapeutic benefit of °Y in both primary and metastatic liver disease, there is an opportunity to explore its application in combination with other available therapies. Studies to assess the potential synergistic therapeutic benefit of °Y and known radio-sensitizers in both metastatic breast and colorectal cancer are warranted. Combination capecitabine and Y present a low toxicity option for breast cancer patients. The potential to improve hepatic tumor response via the synergistic action of selective uptake of 5-FU in the presence of radiation warrants further investigation. °Y in combination with 5-FU, FUDR and capecitabine in colorectal metastases to the liver require further study. Given the potential for super irradiation of liver parenchyma in the presence of these agents, carefully controlled Phase I dose escalation studies are required. [Pg.151]

See other pages where Synergistic action with tumor is mentioned: [Pg.817]    [Pg.549]    [Pg.658]    [Pg.403]    [Pg.148]    [Pg.1231]    [Pg.1283]    [Pg.866]    [Pg.1388]    [Pg.125]    [Pg.1388]    [Pg.366]    [Pg.129]    [Pg.128]    [Pg.148]    [Pg.1231]    [Pg.1453]    [Pg.798]    [Pg.1391]    [Pg.1391]    [Pg.221]    [Pg.396]    [Pg.399]    [Pg.677]    [Pg.798]    [Pg.130]    [Pg.188]    [Pg.669]    [Pg.10]    [Pg.338]    [Pg.187]    [Pg.180]    [Pg.232]    [Pg.557]    [Pg.209]    [Pg.210]    [Pg.2217]    [Pg.156]    [Pg.194]    [Pg.1916]    [Pg.220]   


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