Synera

Dibucaine (Nupercainal) Lidocaine Prilocaine (EMLA, LMX) Lidocaine/Tetracaine Transdermal (Synera)... 

Lidocaine/Tetracaine Transdermal (Synera) [Topical Anesthetic] Uses Topical anesthetic adjunct to phlebotomy or dermal procedures Action Topical anesthetic Dose Adults Children >3 y. Phlebotomy Apply to intact skin 20-30 min prior to venipuncture Dermal procedures Apply to intact skin 30 min prior to procedure Caution [B, ] Contra Pts w/ allergy to... 

Generic Names topical lidocaine/prilocaine, topical lidocaine/tetracaine, tetracaine gel, 4% liposomal lidocaine, 1,1,1,3,3-pentafluoropro-pane and 1,1,1,2-tetrafluoroethane Trade/Proprietary Names EMLA (Eutectic Mixture of Local Anesthetics), Synera", Ametop Gel , LMX-4 , PainEase (vapocoolant spray)... 

Manufacturers (EMLA) Femdale Laboratories, Ferndale, MI (Synera) ZARS Pharma, Salt Lake City, UT (LMX-4) APP Pharmaceuticals, LLC, Schaumburg, IL (Ametop) Smith and Nejiiew, St-Laurent, Quebec (Vapocoolant) Gebauer, Clevdand, OH... 

Since absorption of local anesthetics through the skin is enhanced by heat, a topical patch with an intrinsic heating system was developed [4], This incorporates a controlled heat-assisted delivery system that is physically separated from a eutectic mixture of 70 mg of lidocaine and 70 mg of tetracaine. The surface area of the entire Synera patch is approximately 50 cm, 10 cm of which is active. 

The patch adheres to the skin and when it is exposed to air, the contained heating element is activated and through oxidation releases heat. Local skin temperature remains between 39 and 41°C during the heating phase of application. Systemic absorption is minimal and even with sequential or simultaneous applications of up to four patches, lidocaine plasma levels were low (9-12 ng/mL in adults) and tetracaine levels were essentially non-detectable. The product insert indicates that application of one Synera patch for up to 30 minutes in children 4 months to 12 years of age produced maximum peak plasma concentrations of lidocaine and tetracaine of 63 ng/ mL and 65 ng/mL, respectively. Application of two Synera patches for up to 30 minutes to children 4 months to 12 years of age produced peak lidocaine levels of up to 331 ng/mL and tetracaine levels of less than 5 ng/mL. 

Synera is contraindicated in patients with a known history of sensitivity to lidocaine, tetracaine, or local anesthetics of the amide or ester type. Synera is also contraindicated in patients with para-aminobenzoic acid (PABA) hypersensitivity. 

Synera Amoco A strong, lightweight polypropylene fabric that transports moisture away from the skin Long underwear, jacket lining... 

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