Swelling mouse skin

Phenoi did not cause any signs of skin sensitisation in tests conducted with guinea pigs (modified BuehlerTest, Itoh 1982) and mice (Mouse Ear Swelling Assay, Descotes 1988), and there is no evidence of allergic contact dermatitis in humans. Therefore, labelling with R 43 is not warranted" (p.88). 

Toxicology LD50 (oral, mouse) 350 mg/kg, (IP, mouse) 195 mg/kg, (IV, mouse) 45 mg/kg poison by ing., IP, IV, subcut. routes human systemic effects by intramuscular route potential adverse reactions incl. skin reactions, swelling, continuous asthma attacks, severe allergic reactions, anxiety, nervousness, respiratory arrest... 

Other animal tests have been used to study skin irritation by surfactants or other chemicals and have been reviewed by Gabriel [50]. They are the mouse ear swelling test, the guinea pig immersion technique, the cumulative irritation test on rabbits, and the rabbit ear test. As their usage is continually declining, the reader is referred to Ref. 50 for further details. 

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