Surveillance mechanisms

Recent studies have concentrated on control mechanisms, such as the crucial part played by cyclin dependent protein kinases in triggering chromosome duplication and segregation (Nurse 1990) and surveillance mechanisms (checkpoints) that monitor the fidelity of these two processes (Hartwell Weinert 1989). This focus on control is however a recent phenomenon. Earlier studies, largely... 

Human beings provide the first line of observation and defense for any facility. Periodic or constant first hand operator on site surveillance of the process provides careful observation and reporting of all activities within the facility. Humans have keen senses that have yet to be expertly duplicated by instrumentation devices or sophisticated technical surveillance mechanisms. In this fashion they are more valuable in the observation of system performance than ordinary process control systems may be. 

The access to hepatocytes with liver reconstituting activity is hindered by multiple obstacles, among them the very limited potential to expand hepatocytes in culture. Innate surveillance mechanisms linked to tumor suppressor... 

Nonsense-Mediated Decay and Other mRNA Surveillance Mechanisms Prevent Translation of Improperly Processed mRNAs... 

Nonsense-mediated decay and other mRNA surveillance mechanisms prevent the translation of improperly processed mRNAs encoding abnormal proteins that might Interfere with functioning of the corresponding normal proteins. 

Frischmeyer P.A., van Hoof A., O Donnell K., Guerreiro A.L., Parker R., Dietz H.C. (2002). An mRNA surveillance mechanism that eliminates transcripts lacking termination codons. Science 295 2258-2261. 

In an occupational setting, where prevention of work-related illness is a primary goal, analysis of employee medical information serves as a surveillance mechanism for early detettion of such illness. 

The concept of one irreversible molecular event giving rise to the expression of cancer does not allow for the existence of an absolute threshold. On the other hand, considerations such as the multistage nature of chemical carcinogenesis, the existence of DNA repair and immune surveillance mechanisms, and the existence of threshold doses for other pathological responses support a possible threshold for at least some carcinogenic agents (1) ... 

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