Surface plasmon resonance biomolecular recognition

Nelson RW, Krone JR. Advances in surface plasmon resonance biomolecular interaction analysis mass spectrometry (BIA/MS). J Mol Recognit 1999 12 77-93. [Pg.439]

Nelson, R.W. Krone, J.R. Advances in Surface Plasmon Resonance Biomolecular Interaction Analysis Mass Spectrometry (BIA/MS), J. Mol. Recognit. 12, 77-93 (1999). [Pg.66]

Surface plasmon resonance (SPR) biosensors exploit special electromagnetic waves-surface plasmon-polaritons-to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. A surface plasmon wave can be described as a light-induced collective oscillation in electron density at the interface between a metal and a dielectric. At SPR, most incident photons are either absorbed or scattered at the metal/dielectric interface and, consequently, reflected light is greatly attenuated. The resonance wavelength and angle of incidence depend upon the permittivity of the metal and dielectric. [Pg.138]