Supramolecular virtual combinatorial

Hue, I. Lehn, J. M. Virtual combinatorial libraries Dynamic generation of molecular and supramolecular diversity by self-assembly. Proc. Natl. Acad. Sci. U.S.A. 1997,94,2106-2110. 

Hue, I., Lehn, J. M. (1997). Virtual Combinatorial Libraries Dynamic Generation of Molecular and Supramolecular Diversity by Self-assembly. 

Certain ligand structures are certain to be favored, and others not present at all ( virtual ) [26]. Likewise, certain metal complexes are thermodynamically more stable than others. Since dynamic interconversion is possible on both covalent and supramolecular levels, both ligand and metal preferences may act in concert to amplify a limited subset of structures out of the dynamic library of all possible structures. The preparation of 1 thus represents a sorting of the dynamic combinatorial library of Figure 1.2. 

Fig. 2. A selection of potentially reversible reactions, of interactions, and of intramolecular processes for the dynamic generation of virtual molecular and supramolecular combinatorial...

Supramolecular chemistry thus has a direct relationship with the highly active area of combinatorial chemistry, however in a very specific fashion. Indeed, reversibility being a basic and crucial feature of supramolecular systems, the dynamic generation of supramolecular diversity from the reversible combination of noncovalently linked building blocks falls within the realm of the emerging area of dynamic combinatorial chemistry (DCC) which involves dynamic combinatorial libraries, of either virtual (VCL) or real nature depending on the system and the conditions [45,46], The concepts and perspectives of the DCCA CL approach have been outlined, inter alia with respect to supramolecular polymers [45],... 

The dynamic generation of molecular and supramolecular diversity from the reversible combination of covalently or non-covalently linked building blocks, defines a dynamic combinatorial chemistry (DCC) which gives access to dynamic combinatorial libraries, of either virtual (VCL) or real nature depending on the system and the conditions [18-20]. 

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