Supramolecular diversity

Hue, I. Lehn, J. M. Virtual combinatorial libraries Dynamic generation of molecular and supramolecular diversity by self-assembly. Proc. Natl. Acad. Sci. U.S.A. 1997,94,2106-2110. 

Hue, I., Lehn, J. M. (1997). Virtual Combinatorial Libraries Dynamic Generation of Molecular and Supramolecular Diversity by Self-assembly. 

Supramolecular chemistry thus has a direct relationship with the highly active area of combinatorial chemistry, however in a very specific fashion. Indeed, reversibility being a basic and crucial feature of supramolecular systems, the dynamic generation of supramolecular diversity from the reversible combination of noncovalently linked building blocks falls within the realm of the emerging area of dynamic combinatorial chemistry (DCC) which involves dynamic combinatorial libraries, of either virtual (VCL) or real nature depending on the system and the conditions [45,46], The concepts and perspectives of the DCCA CL approach have been outlined, inter alia with respect to supramolecular polymers [45],... 

The dynamic generation of molecular and supramolecular diversity from the reversible combination of covalently or non-covalently linked building blocks, defines a dynamic combinatorial chemistry (DCC) which gives access to dynamic combinatorial libraries, of either virtual (VCL) or real nature depending on the system and the conditions [18-20]. 

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