Supplements grape seed extract

Furthermore, no one should really expect doctors to keep up with every new little discovery, especially when it comes to supplements. Tell the average doctor that a few capsules of grape seed extract or an amino acid will significantly lower blood pressure, and he or she will likely roll his or her eyes. 

I had brought bottles of two supplements, the Endurance sustained-release arginine and the MegaNatural-BP grape seed extract, for show-and-tell purposes during such interviews and presentations and had some extras. I offered the man the two bottles... 

The conflicting results obtained in vitro versus in vivo may be due to a buffering effect of the food bolus making the condition in the stomach less acidic than required for proanthocyanidin depolymerization (Rios et al 2002). However, proanthocyanidins were not cleaved in the rat stomach even when a grape seed extract was administered by gavage without food (Nakamura and Tonogai 2003). Whether acid-catalysed proanthocyanidin depolymerization occurs in hmnans after consumption of proanthocyanidins without food (e.g. after consmnption from dietary supplements) remains to be determined. 

In other smdy, 20 healthy subjects were supplemented with grape juice (7 mL/kg) for 14 days. Significantly decreased platelet aggregation, increased platelet-derived NO release, and decreased superoxide production were observed. The suppressimi of platelet-mediated thrombosis represents a potential mechanism for the beneficial effects of purple grape products in cardiovascular disease [120]. Similarly, proanthocyanidin-rich extract of grape seed (50 and 100 mg/kg for 3 weeks) had cardioprotective effects against reperfusion-induced injury in isolated rat hearts [121]. A lower dose (36 g of lyophiUzed power grape/day for 4 weeks) was tested in pre- and postmenopausal women. Lipoprotein metabolism, oxidative stress, and inflammatory markers were achieved, and, therefore, CHD risk factors were reduced [122]. 

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