Super disintegrants sodium starch glycolate

Tablets were prepared either with an insoluble (dicalcium phosphate dihydrate), a soluble (6-lactose) or a moderately soluble filler-binder (a-lactose monohydrate). As a disintegrant four different starches (com, rice, potato and tapioca) were used. As a comparison the effect of two super-disintegrants (crospovidone and sodium starch glycolate) was studied. The disintegrants were added at two concentration levels. The compression load was adjusted in order to obtain tablets with comparable initial cmshing strengths.

The four starches used in this study have been proven to be suitable tablet ingredients [19]. Both used super-disintegrants, Primojel (sodium starch glycolate) and Polyplasdone XL (crospovidone), are commonly used as a disintegrant in tablets prepared by direct compression. 

Sodium starch glycolate is a super disintegrant made from cross-linking sodium carboxymethylstarch. Cross-linking involves a chemical reaction with phosphorus oxytrichloride or sodium trimetaphosphate, or a physical... 

For many years, starch was the disintegrating agent of choice. Recently, however, so-called super disinte-grants have been introduced, which markedly reduce tablet disintegration time. Such substances include croscarmellose, crospovidone, polacrilin potassium, and sodium starch glycolate. ... 

In recent times, modified starches especially sodium carboxymethylated derivative, commercially known as sodium starch glycolate (SSG), and pregelatinized starches have been evaluated as super disintegrant (i.e., agent for dispersing the solid drug within a few minutes or making a dispersible tablet). Further, many researchers have explored various other starch sources for sodium carboxymethyl derivative of starch, which is officially known as SSG. ... 

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