Summary An Integrated Hypothesis of NP Formation and Pathology

Blood monocyte recruitment to site of microvascular damage 

Recruited blood monocytes encountering local elevated levels of Ap peptide would then refold the Ap into a fibrillar conformation, thus forming the core of an NP adjacent to a blood vessel [24]. These plaque-bound monocytes differentiate into macrophages and mount an aberrant wound response through the release of neurotrophic and chemotactic agents, inducing an inappropriate ectopic sprouting response toward the 

The Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Genetics Medicine Building, Campus Box 7363, Chapel Hill, 

Structural Genomics Consortium, Oxford University, Oxford 0X3 7DQ, UK 

Annual Reports in Medicinal Chemistry, Volume 45 ISSN 0065-7743, DOI 10.1016/S0065-7743(10)45020-4 

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