Sumatriptan Selegiline

Clinically important, potentially hazardous interactions with dexibuprofen, isocarboxazid, MAO inhibitors, phenelzine, selegiline, St John s wort, sumatriptan, tramadol, tranylcypromine, trazodone... 

Clinically important, potentially hazardous interactions with alprazolam, amphetamines, astemizole, clarithromycin, clozapine, desipramine, dexibuprofen, dextroamphetamine, diethylpropion, droperidol, duloxetine, erythromycin, haloperidol, imipramine, isocarboxazid, linezolid, lithium, MAO inhibitors, mazindol, meperidine, methamphetamine, midazolam, moclobemide, nortriptyline, phendimetrazine, phenelzine, phentermine, phenylpropanolamine, phenytoin, pimozide, pseudoephedrine, selegiline, serotonin agonists, sibutramine, St John s wort, sumatriptan, sympathomimetics, tramadol, tranylcypromine, trazodone, tricyclic antidepressants, troleandomycin, tryptophan, zolmitriptan... 

Selegiline does not interact with sumatriptan or zolmitriptan, and would not be expected to interact with any of the other triptans. Non-selective MAOIs (e.g. phenelzine) are not expected to inter-... 

The interaetion between moelobemide and sumatriptan appears to be established. The same interaetion seems likely to oeeur with any RIMA or non-seleetive MAOI, but not with the seleetive MAO-B inhibitors like selegiline. However, the inereased sumatriptan bioavailability appears not to be elinieally important beeause, in the study eited, those subjeets taking moelobemide did not experienee any more adverse effeets than those taking the selegiline or plaeebo. Despite this the UK manufaeturers of sumatriptan quite elearly say that the eoneurrent use of sumatriptan and MAOIs is eontraindieated both during and for 2 weeks after stopping an MAOI. ... 

Selegiline on the other hand had no effect on the pharmacokinetics of zolmitriptan or its metabolites, apart from a small (7%) reduction in its renal clearance. This finding was expected, since selegiline is specific for monoamine oxidase B (but note that this specificity is lost at higher doses). No special precautions would therefore seem to be necessary if selegiline is given with sumatriptan. 

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