Sulphonamide Related Compounds

Name any two important members of sulphonamide related compounds that are used in chemotherapy of leprosy and bum-therapy. Diseuss the synthesis of one medieal compoimd. 

The tetracyclines (Fig. 6.3) are a large family of related compounds. They were developed after the penicillins and sulphonamides. The first of these... 

This section is devoted mainly to the derivatization and GC of thiols, sulphonic acids and related compounds. The GC of other sulphur compounds (sulphones, sulphonamides, etc.) is also mentioned in other sections, e.g., Pharmaceuticals, Insecticides. 

Investigation of a related indole template, however, yielded potent compounds, as exemplified by the sulphonamide derivative (33). Activity was improved further by introducing steric constraints to the sidechain and introduction of a 7-methyl substituent on the indole ring, leading to compound (34) [82]. Derivatives generally possessed only moderate pharmacokinetic properties however (clearance 25-45 ml/min/kg in dog), which was attributed to metabolic vulnerability of the indole (C2-C3) double bond. Attempts to block metabolism by C2, C3 di-methyl substitution resulted in the loss of oxytocin activity. 

The chemical nature and related physicochemical properties largely govern the distribution and elimination, which refers to biotransformation (metabolism) and excretion, of antimicrobial agents. The majority of antimicrobial agents are weak organic electrolytes, either weak acids (penicillins, cephalosporins, sulphonamides) or weak bases (aminoglycosides, lincosamides, macrolides, diaminopyrimidines, metronidazole), while fluoroquinolones, tetracyclines and rifampin are amphoteric compounds, and chloramphenicol and its... 

---