Sulphonamides and Related Compounds

5M-NaOH, or NHg, or hydrazine, opening up the possibilities of peptide synthesis with satisfactory cleavage of the completed peptide from the polystyrene support.  

Martin, O. Meth-Cohn, and H. Snschitzky, Chem. Comm., 1971, 1319. 

The predominance of the amino-tautomer of an arylsulphonylamidine ArS02N=C(Me)NH2 has been demonstrated by n.m.r. studies (see also ref. 618), and synthetic uses of these compounds include the ring-closure of iodomethanesulphonyl benzamidines to thiadiazolines, by treatment with base, illustrating nucleophilic displacement of iodide from a severely hindered position. Such a displacement is rarely successful. 

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