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Sulphadoxin

Sulphadiazine Sulphathiazole Sulphamerazine Sulphamethazine Sulphamethoxazole Sulphadoxine Sulphaquinoxaline Sulphaphenazole Sulphasalazine 10-Desacetylbaccatine III Baccatine III Erythromycine... [Pg.483]

Titration with nitrous acid is used in pharmacopoeial assays of the following benzocaine, dapsone, primaquine, procainamide, procaine, sulphacetamide, sulphadoxine, sulphamethizole, sulphapyridine and sulphathiazole. [Pg.64]

A simple assay for TMP in bovine tissue and plasma was used. The tissue sample was homogenized with alkaline phosphate buffer and partitioned with dichloromethane. The TMP was reextracted with sulphuric acid. The aqueous layer was mixed with phosphate buffer, and it was further cleaned by SPE according to the previously published assays (174). Sulphadoxine, administered together with TMP, was assayed using TLC densitometry. These assays were used for the study of adsorption and depletion of TMP and SDX from the healthy animals. It was observed that both TMP and SDX were readily adsorbed onto the tissues, but TMP was eliminated much faster than SDX (175). [Pg.667]

Figure 7.19 Ultraviolet trace (270 nm) obtained from SFC of a mixture of (A) sulphadoxine (1-SDX), (B) sulphamethazine (2-SMT), (C) sulpha-merazine (3-SMZ), (D) sulphadimethoxine (4-SDM), (E) sulphadiazine (5-SDZ), (F) sulphaquinoxaline (6-SQX), (G) sulphachlorpyridazine (7-SCP), and (H) sulphathiazole (8-STZ) on a 100 x 4.6-mm ID column packed with 5- tm amino-bonded Spherisorb. The mobile phase was initially carbon dioxide modified with 15% methanol at a flow rate of 4 ml/ min. After 4 min, the concentration of methanol was increased to 25%. Column pressure, 361 bars temperature, 90°C. [Reprinted from Ref. 33, J. Chromatogr. 540, 239 (1991) with kind permission of Elsevier Science Publishers, The Netherlands.]... Figure 7.19 Ultraviolet trace (270 nm) obtained from SFC of a mixture of (A) sulphadoxine (1-SDX), (B) sulphamethazine (2-SMT), (C) sulpha-merazine (3-SMZ), (D) sulphadimethoxine (4-SDM), (E) sulphadiazine (5-SDZ), (F) sulphaquinoxaline (6-SQX), (G) sulphachlorpyridazine (7-SCP), and (H) sulphathiazole (8-STZ) on a 100 x 4.6-mm ID column packed with 5- tm amino-bonded Spherisorb. The mobile phase was initially carbon dioxide modified with 15% methanol at a flow rate of 4 ml/ min. After 4 min, the concentration of methanol was increased to 25%. Column pressure, 361 bars temperature, 90°C. [Reprinted from Ref. 33, J. Chromatogr. 540, 239 (1991) with kind permission of Elsevier Science Publishers, The Netherlands.]...
Synonyms. Sulfadimoxinum Sulformethoxine Sulforthomi-dine Sulphadoxine Sulphormethoxine Sulphorthodimethox-ine. [Pg.978]

Warden WM. Drug displacement from protein binding source of the sulphadoxine liberated by phenylbutazone. Br J Pharmacol 1971 43(2) 325-34. [Pg.2808]

Hellgren U, Rombo L, Berg B, Carlson J, Wiholm BE. Adverse reactions to sulphadoxine-pyrimethamine in Swedish travellers implications for prophylaxis. BMJ (Qin Res Ed) 1987 295(6594) 365-6. [Pg.2988]

Zain RB. Oral lichenoid reactions during antimalarial prophylaxis with sulphadoxine-pyrimethamine combination. Southeast Asian J Trop Med Public Health 1989 20(2) 253-6. [Pg.2988]

Shoaf S E. Schwark W S, Guard C L 1989 Pharmacokinetics of sulfadiazine/trimethoprim in neonatal male calves effect of age and penetration into cerebrospinal fluid. American Journal of Veterinary Research 50 396-402 Taylor W M, Simpson C F, Martin F G 1972 Certain aspects of toxicity of an amicarbalide formulation to ponies. American Journal of Veterinary Research 33 533-541 Watkins W M, Mosobo M 1993 Treatment of Plasmodium falciparium malaria with pyrimethamine and sulphadoxine a selective pressure for resistance is a function of long elimination half-life. Transactions of the Royal Society of Tropical Medicine and Hygiene 87 75-79... [Pg.62]

Nielsen, P. Rasmussen, F. (1976) Influence of age on half-life of trimethoprim and sulphadoxine in goats. Acta Pharmacologica et Toxicologica, 38,113-119. [Pg.265]

Sulphadoxine, the most commonly used sulpha drug is a structural analogue of pABA and acts as a competitive inhibitor of plasmodial DHPS. Resistance to sulphadoxine in P. falciparum involves amino acid substitutions in DHPS that alter enzyme function. Resistance to... [Pg.136]

Dua, V.K. Sarin, R. Sharma, V.R Sulphadoxine concentrations in plasma, red blood ceUs and whole blood in healthy and Plasmodium falciparum malaria cases after treatment with Fansidar using high-performance liquid chromatography. J.Pharm.Biomed.Anal., 1994, 12, 1317-1323... [Pg.1264]

Karbwai J, Bunnag D, Breckenricfee AM, Back DJ. The pharmacokinetics of mefloquine when given alcme or in combination with sulphadoxine and pyrimefliamine in Thai male and female subjects. EurJ Clin Pharmacol (198 32,173-7. [Pg.234]

Pyrimethamine and sulphadoxine were extracted from plasma and separated on a C 8 column (A = 240nm) using a 65/20/15/0.1 water/acetonitrile/methanol/ triethylamine mobile phase [1498]. Peak shapes were excellent and baseline resolution was achieved in 12 min. The reported linear range and detection limit for pyrimethamine was 6.25-2000 ng/mL and 7 ng/mL, and for sulpha-doxine were 0.625 pg/mL and 15 ng/mL. [Pg.514]

See other pages where Sulphadoxin is mentioned: [Pg.659]    [Pg.137]    [Pg.158]    [Pg.263]    [Pg.184]    [Pg.1608]    [Pg.3225]    [Pg.44]    [Pg.160]    [Pg.222]    [Pg.226]    [Pg.226]    [Pg.227]    [Pg.449]    [Pg.104]    [Pg.136]    [Pg.259]    [Pg.187]    [Pg.395]    [Pg.397]    [Pg.400]    [Pg.264]    [Pg.52]   
See also in sourсe #XX -- [ Pg.36 , Pg.371 , Pg.441 , Pg.449 ]



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