Sulfonamides skin eruptions with

Other skin eruptions seen with sulfonamides include erythema multiforme, vesicular and bullous rashes, and exfoliative dermatitis (144). In erythema multiforme, linear depositions of IgA at the dermoepidermal junction have been suggested to play a pathogenic role (132). 

All sulfonamides, including antimicrobial sulfas, diuretics, diazoxide, and the sulfonylurea hypoglycemic agents, have been considered to be partially cross-allergenic. Flowever, evidence for this is not extensive. The most common adverse effects are fever, skin rashes, exfoliative dermatitis, photosensitivity, urticaria, nausea, vomiting, diarrhea, and difficulties referable to the urinary tract (see below). Stevens-Johnson syndrome, although relatively uncommon (ie, < 1% of treatment courses), is a particularly serious and potentially fatal type of skin and mucous membrane eruption associated with sulfonamide use. Other unwanted effects include stomatitis, conjunctivitis, arthritis, hematopoietic disturbances (see below), hepatitis, and, rarely, polyarteritis nodosa and psychosis. 

Immunologic Ocular administration of dorzolamide and timolol (doses not stated) in a woman with glaucoma led to the development of a disseminated eruption associated with severe thrombocytopenia [4 ]. A skin biopsy showed hyperkeratosis, acanthosis, and perivascular and periadnexal infiltrates without vasculitis. The skin reaction resolved after withdrawal of dorzolamide and treatment with an antihistamine, but the thrombocytopenia persisted. Subsequent treatment with dapsone led to a recurrence of the skin changes this pattern is consistent with sulfonamide hypersensitivity syndrome [SEDA-30, 252]. 

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