Sulfo transferase enzyme

This enzyme [EC 2.S.2.3], also known as arylamine sulfo-transferase, catalyzes the reaction of 3 -phosphoadeny-lylsulfate with an arylamine to produce adenosine 3, 5 -bisphosphate and an arylsulfamate. Primary and secondary amines which can act as substrates include aniline, 2-naphthylamine, cyclohexylamine, and octylamine. 

Intestinal monoamine oxidase (MAO) metabolizes drugs such as sumatriptan,31 phenylephrine,32 and other amine-containing drugs. A number of hydrolytic and phase II enzymes, such as acetyl transferases, glutathione-S-transferases, methyl transferases, sulfo transferases, and UDP-glucuronosyl transferases, are also present in the intestinal mucosa (see Table 2.2). The amounts of metabolic enzymes decrease... 

The vitamin also activates serine palmitoyltransferase, the first enzyme of phosphosphingolipid synthesis, and in bacteria it can, together with inorganic phosphate, replace part of the ATP requirement of galactocerebroside sulfo-transferase (Tsaioun, 1999). In animals, lipid sulfatides are decreased in vitamin K deficiency and increased with higher intakes (Sundaram et al., 1996). 

For reasons of completeness the reactions catalyzed by three different sulfo-transferases are also included in the figure. On the basis of the sequences of the two sulfotransferases of this group that have been cloned so far it seems that these enzymes have a domain structure that strongly resembles that of a Golgi glycosyl-... 

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