Sulfated polysaccharides polymers

Heparin is a large sulfated polysaccharide polymer obtained from animal... 

De Clercq E. Anti-HIV activity of sulfated polysaccharides. In Yalpani M, ed. Carbohydrates and Carbohydrate Polymers, Analysis, Biotechnology,... 

Pavao, M. S. G., Rodrigues, A. M., and Mourao, P. A. S. (1994). Acidic polysaccharides of the Ascidian styeloplicata. Biosynthetic studies of the sulfated L-galactans of the tunic and preliminary characterization of a dermatan sulfate-like polymer in body tissues. Biochem. Biophys. Acta 1199, 229-237. 

In addition to valuable physicochemical properties, sulfated polysaccharides of the red algae are promising biologically active polymers, and many structural works already cited aimed at isolation and characterization of new compounds having potential medical application. The most important types of biological activity of sulfated galactans are listed briefly in this section. 

D. A. Navarro, M. L. Flores, and C. A. Stortz, Microwave-assisted desulfation of sulfated polysaccharides, Carbokydr. Polym., 69 (2007) 742-747. 

M. C. Matulewicz and A. S. Cerezo, Water-soluble sulfated polysaccharides from the red seaweed Chaetangiumfastigiatum. Analysis of the system and the structures of the a-D-( 1 —>3)-linked mannans, Carbohydr. Polym., 7 (1987) 121-132. 

The action of aqueous hydrazine on sugar sulfates is different from that of anhydrous hydrazine on sulfated polysaccharides of the chondroitin type. Anhydrous hydrazine is a reagent for cleaving the amide linkage in, for instance, proteins. It has been applied to chondroitin A sulfate to effect Af-deacetylation, and then gave a partly desulfated, as well as N-deacetylated, polymer. In contrast, the aqueous hydrazine reagent has no effect on chondroitin sulfates A and C. ... 

Heparin (see here) is a heterogeneous polysaccharide polymer of D-iduronate-2-sulfate linked oi l->4 to N-sulfo-D-glucosamine-6-sulfate. This repeating unit of the polymer is shown at the right. 

A complete list of semi-synthetic heparinoids is outside the scope of this article. Products of sulfation of neutral polysaccharides include sulfates of starch, cellulose, - - xylan, dextran, " guaran, and synthetic polymers of o-glucose. A somewhat closer simulation of the structure of heparin was attempted by sulfating polysaccharides containing amino sugars or uronic acids or both, such as chitin and chitosan, " and the corresponding N-formyl, N-(car-boxymethyl), O-(carboxymethyl), and 5-carboxylated - deriva-... 

Alban S, Schauerte A, Franz G (2002). Anticoagulant sulfated polysaccharides Part I. Synthesis and structure-activity relationship of new pullulan snlfates. Carbohyd. Polym. 47 267-276. 

Wijesinghe, W. A. J. P., Athukorala, Y., and Jeon, Y. J. (2011). Effect of anticoagulative sulfated polysaccharide purified from enzyme-assistant extract of a brown seaweed Ecklonia cava on Wistar rats. Carbohydr. Polym. 86, 917-921. 

Wijesekara, 1., Pangestuti, R., and Kim, S.-K. (2011). Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae. Carbohydr. Polym. 84, 14-21. 

Our experimental approach is mainly based on the use of mlcr calorimetric, potentlometric, and chirooptical techniques. Polymers considered include 1] sulfated polysaccharides (i-carragee-nan, dextran sulfate] ... 

S. Alban, A. Schauerte, G. Franz, Anticoagul t sulfated polysaccharides part I. synfiiesis and structure-activity relationships of new pullulan sulfates, Carbohydr. Polym. 47 (3) (2002) 267—276. 

The sulfated polysaccharide, heparin, is used as a powerful anticoagulant and acts by inhibiting one of the later stages in the interaction cascades leading to clot development (20, ij). This action is intimately associated with the negative charge on the molecule, for a number of other sulfated polysaccharides are also effective (43-45), and polysaccharides and synthetic polymers with quartemary ammonium functions act as heparin antagonists (46). 

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