Sulfated polysaccharides antiviral effect

Emphasis in the initial phase of our work was placed on sulfated polysaccharides that are antiviral. Not only were the desired rheological properties and long-term stability achieved in DCE formulations, the activity of the dextran sulfate or N9 were not compromised. DCE formulations containing DS display strong anti-HIV activity in vitro in comparison with negative (not shown) and positive controls (Figure 2). This is an important first step in the screening process towards clinical effectiveness. 

There are many classes of chemical compounds with putative antiviral effects. One such class is known broadly as sulfated polysaccharides (SPs). They... 

From the marine bacterium Pseudoalteromonas sp. AM, an exopolysaccharide (EPS) was isolated which exhibited significant antiviral activity towards Herpes simplex (HSV-I). The effect resulted in the inhibition of virus replication of 60% when HSV-I was treated with 10% of EPS [81]. A similar result was reported in a previous paper of Matsuda et al. They described the antiviral effect, evaluated in RPMI8226 cells infected with HS V-1 virus, of a sulfated polysaccharide produced by a marine Pseudomonas species WAK-1 strain [82]. 

Two polysaccharides, PI and P2, isolated from Azadirachta indica leaves, and their respective chemically sulfated derivatives, PIS and P2S, were evaluated for their activity in the replication of polivirus type 1 in HEp-2 (epithelial cells of hiunan larynx carcinoma) cell cultures. Such compoxmds exhibited a strong antiviral activity with an ICjg of 80 microg/mL, 37.5 microg/mL, 77.5 microg/mL and 12.1 microg/mL for PI, PIS, P2 and P2S, respectively. The best antiviral effect was detected when the... 

Yamamoto, N., Nakashima, H., Yoshida, O., Kaneko, Y, Matsuzaki, K., and Uryu, T. (1989) Effect of the sulfated polysaccharides on HIV a novel strategy of chemical modification for HIV antivirals. Arch. AIDS Res., 1,45-56. 

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