Sulfadiazine liquid chromatographic methods

Simeonidou et al. (238) reported an ion-pair liquid chromatographic method for the determination of sulfadiazine, sulfamethazine, sulfadimethoxine, and sulfaquinoxaline residues in chicken muscle. According to this method, a 3 g ground tissue sample is extracted with 30 ml chloroform. Following centrifugation the supernatant is filtered and a 10 ml aliquot is extracted with 1 ml 3N hydrochloric acid and submitted to precolumn derivatization with fluorescamine. Liquid chro-... 

Long, A.R. Hsieh, L.C. Malbrough, M.S. Short, C.R. Barker, S.A. A multiresidue method for the isolation and liquid chromatographic determination of seven sulfonamides in infant formula. J.Liq.Chromatogr., 1989, 12, 1601-1612 [extracted sulfadiazine, sulfadimethoxine, sulfamerazine, sulfamethazine, sulfathiazole, sulfisoxazole column temp 45 SPE]... 

Sulfonamides having a free j )-amino group are readily assayed by titration with nitrous acid. The sulfonamide function may also be titrated with base, such as lithium methoxide. The majority of the sulfas listed in the U.S. Pharmacopeia XXII, however, are assayed by chromatographic methods, particularly high performance liquid chromatography (49). Sulfonamides for which assays are listed in the U.S. Pharmacopeia XXII-National Formulary XVII include the following sulfacetamide, sulfabenzamide, sulfadiazine, sulfadoxine, sulfamerazine, sulfamethazine, sulfamethizole, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfathiazole, sulfinpyrazone, sulfis ox azole, sulfisoxazole acetyl, sulfisoxazole diolamine, sulfoxone, triple sulfa, dapsone, and various combinations with prednisolone, pyrimethamine, and trimethoprim. 

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See also in sourсe #XX -- [ , , , ]

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