Sugars/carbohydrates inhibitory concentrations

Since the ceramide portions of more and less inhibitory glycoliplds are very similar, differential Inhibition of antiviral activity of mouse fibroblast interferon must be related to their carbohydrate side chains. We therefore assayed antiviral activity in the presence of various saccharides contained in gangiiosides. As seen in Figure 3, both N-acetylneuraminyl lactose and N-acetyl-neuraminic acid inhibited antiviral activity, requiring approximately equal concentrations to obtain complete inhibition (60 mM). However, in comparison to GM3, 600-fold higher concentrations of these sugars had to be employed to yield complete inhibition of antiviral activity. N-glycolyineuraminic acid and the 6-methyi-... 

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