Sugar glycoconjugates

Bulter, T. and Elling, L. (1999) Enzymatic synthesis of nucleotide sugars. Glycoconjugate Journal, 16, 147-159. 

Other disorders in which glycoproteins have been implicated include hepatitis B and C, Creutzfeldt-Jakob disease, and diarrheas due to a number of bacterial enterotoxins. It is hoped that basic smdies of glycoproteins and other glycoconjugates (ie, the field of glycobiology) will lead to effective treatments for diseases in which these molecules are involved. Already, at least two disorders have been found to respond to oral supplements of sugars. 

Dondoni, A. Massi, A. (2006) Design and Synthesis of New Classes of Heterocyclic C-Glycoconjugates and Carbon-Linked Sugar and Heterocyclic Amino Acids by Asymmetric Multicomponent Reactions (AMCRs). Accounts of Chemical Research, 39, 451M63. 

Recent applications of HPAEC-PAD are many and varied. A representative list includes quantitation of polyglucose metabolites in plasma of dialysis patients,148 analysis of heat-treated milk,149 carbohydrate content in lipopolysaccharides,150 phosphorylated sugars in tissue samples,151 composition of soybean meal,152 carbohydrate composition of recombinant modified tissue plasminogen activator,153 analysis of cyclization products from an enzyme reaction,154 carbohydrate content of glycoconjugate vaccines,155 and monitoring of patients with rheumatoid arthritis.156... 

Y. Mikata, Y. Onchi, K. Tabata, S.-i. Ogura, I. Okura, H. Ono, and S. Yano, Sugar-dependent photocytotoxic property of tetra- and octa-glycoconjugated tetraphenylporphyrins, Tetrahedron Lett., 39 (1998) 4505 -508. 

H. Kato, C. Bottcher, and A. Hirsch, Sugar balls synthesis and supramolecular assembly of [60]fullerene glycoconjugates, Eur. J. Org. Chem. (2007) 2659-2666. 

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