Sugano

T. Sugano, ed.. Gallium, Arsenide, and Belated Compounds, No. 63, Institute of Physics, Bristol, U.K., 1982. 

Jptt Piit. 1,087,621 (1987), I. Takahashi andT. Sugano (to Daicel Chem. Ind.). 

Talspeak process, 6, 959,960 Tanabe-Sugano diagrams, 1, 238 Tannic acid in gravimetry, 1, 524 Tanning... 

Sugano M, Fujikawa T, HiratsujiY, NakashimaK, FukudaN, Hasegawa (1980) Am J Clin Nutr 33 787... 

The figure below abstracts just the spin-triplet part of the Tanabe-Sugano diagram in the previous box. Suppose we have recorded the electronic d-d spectrum of [V(H20)6] and identified two out of the three possible spin-allowed (triplet-triplet) bands at energies 17,200 cm and 25,600 cm ... 

IKEDA I, IMASATO Y, SASAKI E, NAKAYAMA M, NAGAO H, TAKEO T, YAYABE F, SUGANO M (1992) Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats. Biochim Biophys Acta. 1127 141-6. 

Immune complexes enhancement (Nicolosi et al., 1993). Reduction of serum cholesterol and LDL-C elevation of HDL-C (Seetharamiah and Chandrasekhara, 1989 Raghuram et al, 1989 Rukmini and Raghuram, 1991 Lichtenstein et al., 1994 Sugano and Tsuji, 1997). Hypolipidemic effect (Lichtenstein et al., 1994). 

Regulation of fasting serum glucose, improvement of glucose utilization, improvement in energy. Beta-cells activation and enhancement of insuhn production (Sugano et al., 1984). 

Cardiovascular disease (CVD) is characterized by the involvement of the heart and allied vascular system. High cholesterol, associated lipid abnormahties and high blood pressure are recognized as the major risk factors of CVD. There have been several animal experiments and clinical studies using rice bran and rice bran oil, which have demonstrated a hypocholesterolemic effect (Raghuram et al., 1989 Rukmini and Raghuram, 1991 Sugano and Tsuji, 1997). The mechanisms involved are briefly summarized. 

SUGANO M (1979) Antidandruff and anti-itching shampoo. J P 7936306 (Chem Abstr, 1979, 87 78764a). 

SUGANO M, ISHIWAKI N, NAKASHIMA K (1984) Dietary protein-dependent modification of serum cholesterol level in rats significance of Arginine/lysine ratio. rinw Nutr Metab, 28 192-9. 

Sugano, H. Artifidal membrane technologies to assess transfer and permeation of drugs in drug discovery. In ADME/Tox Approaches, Tests, B.,... 

Sugano, K., Hamada, H., Machida, M., Ushio, H. High throughput prediction of oral absorption improvement of the composition of the lipid solution used in parallel artifidal membrane permeation assay. J. Biomol. Screen. 2001, 6,189-196. 

Omata S, Kasama H, Hasegawa H, Hasegawa K, Ozaki K, Sugano H. 1986. Species difference between rat and hamster in tissue accumulation of mercury after administration of methyhnercury. Arch Toxicol 59 249-254. 

Sugano et al. [561,562] explored the lipid model containing several different phospholipids, closely resembling the mixture found in reconstituted brush border lipids [433,566] and demonstrated dramatically improved property predictions. The best-performing lipid composition consisted of a 3% wt/vol lipid solution in 1,7-octadiene (lipid consisting of 33% wt/wt cholesterol, 27% PC, 27% PE, 7% PS, 7% PI). The donor and acceptor compartments were adjusted in the pH interval between 5.0 and 7.4 [562]. With such a mixture, membrane retention is expected to be extensive when lipophilic drugs are assayed. The use of 1,7-octadiene in the assay was noted to require special safety precautions. 

Sugano et al. [562] also studied the effect of PEG400, DMSO, and ethanol, up to 30%, in their PAMPA assays. In general, water-miscible cosolvents are expected to... 

Five-lipid formula as reported by Sugano, except 1,7-octadiene was substituted with dodecane. 

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