Suboptimal strategies

Similarly, when tax planning is performed independently from supply chain planning, it may lead to suboptimal strategies with respect to operating cost and profit. 

The situation is not different in the pharmaceutical world, where marketing strategies are developed on the basis of expectations of their effects on drug sales, market penetration, perceived quality, etc. Such strategies are often the product of implicit mental models, and are effective when they have their desired impact. But mental models are difficult to communicate, impossible to analyze or quantify, and hard to prioritize. As such, they often result in suboptimal decisions when it comes to strategy development and brand planning. 

Desymmetrizations by C—H insertion using diazo decomposition strategies is well established. Chiu and coworkers have recently applied this strategy to the oxabicyclic system 195. A ferf-leucine-derived Rh(II) catalyst provided the best results [Eq. (10.58a)]. Wardrop and coworkers have applied a similar strategy en route to sordidin unfortunately, both yield and ee proved to be suboptimal [Eq. (10.58b)] ... 

Instead of focusing strictly on the pharmacy profession, the fourth conference addressed the quality of the entire medication-use system. The objectives were to describe—and publicize—the extent of preventable morbidity, mortality, and excess costs resulting from suboptimal medication use to stimulate discussion of the social and economic impact of dysfunction in the medication-use system to develop a reengineered system for medication use that would optimize clinical, economic, and humanistic outcomes to identify strategies that could be used to evaluate and implement the models developed and to foster greater interprofessional collaboration and a shared commitment to optimal medication use. 

For small numbers of decisions, say up to 10-15, total enumeration is recommended, regardless of relaxation quality. As the number of binary decisions increases, models subdivide into three regions. In the outermost, relaxations are too poor to assist in analysis. The only practical strategy is some form of heuristic search lacking even a bound on the suboptimality of results obtained. 

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