Subchronic toxicity tests

Norberg, TJ. and D.I. Mount. 1985. A new fathead minnow (Pimephales promelas) subchronic toxicity test. Environ. Toxicol. Chem. 4 711-718. 

Subchronic toxicity tests (90 days) of several species showed dogs to be the most sensitive mammals to 2,4- and 2,6-DNT 5mg/kg/day and 4mg/kg/day were no-effect levels for the two... 

Table 21.6 Tissues and Organs to Be Examined Histologically in Chronic and Subchronic Toxicity Tests...

Chapter 6. Chan, P. K., and A. W. Hayes Principles and methods for acute and eye irritancy. Chapter 7. Mosberg, A. T., and A. W. Hayes Subchronic toxicity testing. 

Subchronic Toxicity Tests with Rodents and Non-Rodents... 

See also Ames Test Analytical Toxicology Animal Models Dominant Lethal Tests Dose-Response Relationship Host-Mediated Assay In Vitro Test In Vivo Test Mouse Lymphoma Assay Toxicity, Acute Toxicity, Chronic Toxicity Testing, Irritation Toxicity Testing, Modeling Toxicity, Subchronic Toxicity Testing, Validation. 

Subchronic and chronic toxicological data (subchronic-toxicity tests, 3 months chronic-toxicity tests 2 years. Chronic-toxicity tests include carcinogenicity and reproduction tests (3 generations), residue dynamics, and metabolism and degradation data (metabolism tests in animals will be required after 1980)... 

In May 1979, EPA sponsored a workshop in Denver, Colorado, to review their proposed guidelines for subchronic toxicity testing. Attendance was limited to invited participating and observer scientists from academia, public interest groups. 

West, B.J., C.X. Su, and C.J. Jensen. 2009. Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia (noni) fruit. Review of noni update. /. Toxicol. Sci. 34(5) 581-585. 

In Chemical Manufacturers Association v. EPAf the court examined a challenge to EPA s test rule for ethylhexanoic acid (EHA), a chemical substance consumed in the manufacturing process and thus causing no exposure to consumers, but which the EPA asserted workers were exposed to. The rule required a ninety day subchronic toxicity test, a developmental toxicity test, and a pharmacokinetics test. The D.C. Circuit identified two primary issues ... 

Many manufacturers can provide biocompatibility data either in their literature or as an FDA Master File. Often material manufacturers will advertise that a material meets class IV biocompatibility requirements. Class VI requirements are an old set of tests published in the U.S. Pharmacopeia that were developed for testing food packaging. They are similar to the cytotoxicity, acute toxicity, and subchronic toxicity tests. However, the data provided by a materials manufacturer are on samples that have not seen the processing and storage of the device. The data simply are an indication that the material can pass the initial set of biocompatibility tests if processed appropriately. 

Table 5.3. Sample Subchronic Toxicity Tests and Commonly Used Species...

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