Study Data Tabulation Model

See also Clinical Data Interchange Standards Consortium Study Data Tabulation Model. 

The type of data standards that will be implemented should be stated. For example, datasets will be created using Study Data Tabulation Model (SDTM) and Analysis Data Model (ADaM) standards (as specified by the Clinical Data Interchange Standards Consortium at http //... 

Both approaches to study day calculation are used in the pharmaceutical industry, although the algorithm in Program 4.3 is probably used more often. The CDISC Submission Data Tabulation Model states that you should use the algorithm in... 

For purposes of data correlation, model studies, and scale-up, it is useful to arrange variables into dimensionless groups. Table 6-7 lists many of the dimensionless groups commonly founa in fluid mechanics problems, along with their physical interpretations and areas of application. More extensive tabulations may oe found in Catchpole and Fulford (Ind. Eng. Chem., 58[3], 46-60 [1966]) and Fulford and Catchpole (Ind. Eng. Chem., 60[3], 71-78 [1968]). 

Before experimentally measuring the partition coefficients of our 15 trifluoromethanesulfonanilide (TFMS) series members, we too had given serious consideration to approximating the TFMS substituent tt values with appropriately chosen ir values from one of the above-mentioned parent series studied by Fujita et al. (II). The appropriate choice of an approximating parent compound was difficult to make, however, as can be judged from the ionization and partitioning data tabulated in Table III for several reasonable model series chosen from Ref. II. 

The two solid residues were first subjected to elemental analysis using the Perkin-Elmer Model 240C Elemental Analyzer and Model 240DS Data Station. The analyzer was employed using both the normal CH N mode as well as the sulfur mode of operation. The ash content of the residues were established by weighing the sample before and after analysis in the 240C Elemental Analyzer. The results of these studies are tabulated in Table 2. As is seen in the table, the most outstanding difference in the results is the ash and sulfur values... 

A tabulation of the partial pressures of sulfuric acid, water, and sulfur trioxide for sulfuric acid solutions can be found in Reference 80 from data reported in Reference 81. Figure 13 is a plot of total vapor pressure for 0—100% H2SO4 vs temperature. References 81 and 82 present thermodynamic modeling studies for vapor-phase chemical equilibrium and liquid-phase enthalpy concentration behavior for the sulfuric acid—water system. Vapor pressure, enthalpy, and dew poiat data are iacluded. An excellent study of vapor—liquid equilibrium data are available (79). 

A certain kind of radical transfer can be modelled by the transfer of a hydrogen atom from an alkane molecule to a small alkyl radical. This reaction was studied in detail in the gas phase. With hydrocarbon partners, heats of reaction are a fairly safe measure of the relative rate of transfer, as the pre-exponential Arrhenius factors remain approximately constant for a series of transfers to a given radical. Tabulated thermodynamic data indicate, however, [31, 32] that the correlation between the heat of reaction and the transfer rate is not valid for reactions of a radical with polar substrates [32, 33], In condensed phases, transfer reactions have not been sufficiently studied. Polymerizations themselves are the source of the most valuable, though incomplete, information. 

Many physical properties undergo dramatic changes in value as water is heated and pressurized from sub- to supercritical conditions, particularly in the region of the critical point where some properties such as heat capacity reach a singularity. This change in behavior means that more familiar correlations of properties measured at subcritical conditions are likely to be inaccurate when applied at supercritical conditions. There have been some experimental studies performed to measure, tabulate, and in some cases correlate values of key properties of supercritical water, such as the self-diffusion coefficient, viscosity,thermal conductivity," heat capacity at constant volume," dielectric constant," and selfdissociation constant." " Far more work has been devoted to calculation of property values from models fitted empirically to data or developed more rigorously through molecular simulation. For PVT data and its derivatives, several attempts... 

The components of an ion-association aqueous model are (1) The set of aqueous species (free ions and complexes), (2) stability constants for all complexes, and (3) individual-ion activity coefficients for each aqueous species. The Debye-Huckel theory or one of its extensions is used to estimate individual-ion activity coefficients. For most general-purpose ion-association models, the set of aqueous complexes and their stability constants are selected from diverse sources, including studies of specific aqueous reactions, other literature sources, or from published tabulations (for example, Smith and Martell, (13)). In most models, stability constants have been chosen independently from the individual-ion, activity-coefficient expressions and without consideration of other aqueous species in the model. Generally, no attempt has been made to insure that the choices of aqueous species, stability constants, and individual-ion activity coefficients are consistent with experimental data for mineral solubilities or mean-activity coefficients. 

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