Studies on the Urinary Bladder and Internal Urethral Sphincter

Studies on the Urinary Bladder and Internal Urethral Sphincter 

Several authors investigated the influence of drugs on isolated parts of the lower urinary tract. Ueda et al. (1984) studied the effects on smooth muscle of the rabbit bladder dome, trigone and proximal urethra. 

Male New Zealand rabbits weighing 2-3 kg are eu-thantized under anesthesia and the abdomen is opened to remove the bladder and the urethra. After excess fat and connective tissue is removed, the bladder and the urethra are dissected into dome, trigone and proximal urethral preparations. All strips are cut transversely being approximately 2-6 mm unstretched. 

The values are expressed or plotted as the means SE and pA2 values are calculated according to Arunlakshana and Schild (1959). Data are analyzed using the t-test, analysis of variance, Dunnett s test and 

Pietra et al. (1990) studied the effects of some antidepressants by the in vitro inhibition of carbachol-induced contractions of rat detrusor strip preparations. The detrusor muscle tissue (bladder dome) was cut in a semicircular direction and further dissected into strip preparations measuring approximately 2 x 20 mm. 

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