Structure of Human Cystatin C and Its Concentration in Body Fluids

Structure of Human Cystatin C and Its Concentration in Body Fluids [Pg.72]

The complete amino acid sequence of the single polypeptide chain of human cystatin C was determined in 1981 (Gil) and later corroborated by identification and sequencing of the corresponding cDNA (Fig. 4) (A3) and gene (A5, A7). [Pg.72]

The three-dimensional structure of cystatin C is not yet determined, although some crystallographic data are available (K8), but it can be presumed that it is similar to that described for the homologous protein chicken cystatin (B19) and this has, at least partially, been confirmed by NMR studies (El). A schematic structure for human cystatin C is given in Fig. 1. [Pg.72]

Serum/Plasma Cystatin C as a Marker for Glomerular Filtration Rate (GFR) [Pg.72]

No investigations have demonstrated that the diagnostic usefulness of the serum level of cystatin C is different from that of the plasma level of cystatin C. The term [Pg.72]

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