Structure-binding relationships

Figure 6. Structure-binding relationships of various antisera for cannabinoids...

Charts I, II, III and IV illustrate the kinds of hosts that have been designed and synthesized and the relationships between their structures and abilities to bind lithium, sodium, potassium and cesium picrates, respectively. The differences in structural recognition by a particular guest in complexing a variety of possible hosts are measured by the differences in the - AG values listed below each structure. For lithium picrate, the values range from >23 to <6 kcal mol for sodium picrate, from 19.2 to < 6 kcal mol" for potassium picrate, from 17.1 to < 6 kcal mol" for cesium picrate, from 13.1 to < 6 kcal mol The principles of complementarity and preorganization are illustrated repeatedly in the structure-binding relationships found in these charts [3]. Only a few relationships will be discussed. 

Adamczyk, M. Grote, J. Moore, J. A. Rege, S. D. Yu, Z. Structure-binding relationships for the interaction between a vancomycin monoclonal antibody Fab fragment and a library of vancomycin analogs and tracers. Bioconjugate Chem. 1999, 10, 176-185. 

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