Cannabinoid structure binding relationships

Figure 6. Structure-binding relationships of various antisera for cannabinoids...

Compton DR, Rice KC, De Costa BR, Razdan RK, Melvin LS, Johnson MR, and Martin BR (1993) Cannabinoid structure-activity relationships correlation of receptor binding and in vivo activities. J Pharmacol Exp... 

The structure-activity relationships of dronabinol (32) on cannabinoid receptor activity have been investigated (see Table 15.14). Both the phenolic hydroxyl group and the C3 alkyl chain in (32) are critical for binding affinity. 

Melvin LS, Milne GM, Johnson MR, Subramaniam B, Wilken GH, Howlett AC (1993) Structure-activity relationships for cannabinoid receptor-binding and analgesic activity studies of bicyclic cannabinoid analogs. Mol Pharmacol 44 1008-1015... 

Many of these synthetic cannabinoids are used in pharmacological studies involving structure-activity relationships, receptor binding studies, and detailed mechanisms of action of these drugs. Some synthetic cannabinoids have been used for medicinal purposes including rimonabant, nabilone, and dronabinol. Rimonabant is a selective CBl receptor antagonist which was used to treat obesity for some time, but was withdrawn from the market because it showed severe side effects such as severe depression [70]. Rimonabant was the first selective CBl receptor blocker to be approved for use... 

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